TRIMITONEX

Indications

• Pruritus associated with scabies
• Pruritus due to sunburn
• General pruritus

Dosage

Children: For children aged 1 month to 2 years, apply as directed by a doctor; for children aged 3 to 17 years, apply 2-3 times a day.

Adults: Apply 2-3 times a day to the affected area.

Mechanism of action

Crotamiton is toxic to the scabies mite and relieves itching by producing a counter-irritation effect. As it evaporates from the skin, it creates a cooling sensation, which diverts attention from the itching. The exact mechanism by which crotamiton kills scabies is not fully understood.

Pharmacodynamics

Crotamiton is effective in alleviating pruritus, particularly in cases related to scabies or sunburn. Its cooling effect is beneficial in managing itching, as it distracts from the discomfort. This drug's antiparasitic properties help eliminate scabies mites, although the specific pathway involved remains unclear.

Pharmacokinetics

Crotamiton is applied topically, allowing for localized effects with minimal systemic absorption. The drug's pharmacokinetic profile involves rapid evaporation from the skin surface, which contributes to its cooling effect and antipruritic action. There is limited information available on its absorption, distribution, metabolism, and excretion in the human body.

Contra-indications

• Hypersensitivity to crotamiton or any excipients
• Acute exudative dermatoses
• Obstructive jaundice
• Endocrine disease
• Chronic renal disease
• Iron deficiency
• Certain malignant diseases
• Use on broken skin
• Use near mucosal surfaces

Adverse effects

• Local irritation
• Erythema
• Burning sensation
• Allergic reactions
• Drowsiness (when used for longer than recommended)

Precautions

• Avoid use on very inflamed skin
• Avoid excessive application
• Use on doctor’s advice for children under 3 years
• Avoid contact with eyes and mucous membranes

Pregnancy

Manufacturer advises to avoid, especially during the first trimester; no information available.

Breast-feeding

No information available; avoid application to nipple area.

Storage

Store at room temperature, away from moisture and direct light.

Formulations

• Cream

Mechanism of action

Crotamiton is an antiparasitic that is toxic to the scabies mite. Crotamiton also relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your body's attention away from the itching.

Pharmacodynamics

Crotamiton is usually used to treat pruritis (itching of the skin) caused by scabies or sunburn. Crotamiton relieves itching by producing what is called a counter-irritation. As crotamiton evaporates from the skin, it produces a cooling effect. This cooling effect helps to divert your body's attention away from the itching. Due to this cooling effect it is also effective for the relief of sunburn. The drug is also believed to kill scabies through an unknown mechanism.