TRISOLIV 500MG/ 500MCG SYRUP
TRICHOLINE CITRATE & KALMEGH
What it does
Kalmegh is a herbal remedy often used to support liver health and boost the immune system.
Commonly used for: liver problems (hepatitis), digestive issues, immune system support
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
Ask about this medicine
Answers come only from this medicine's registration record, BNF monograph and interaction data - not medical advice.
Medicine sourcing is available in Kenya only. We don't sell or dispense medicines - licensed pharmacies do.
Sourcing - Kenya onlyRegistration & product details
Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:38 · updated 2026-09-26 04:30:27
About kalmegh
Kalmegh is a herbal remedy often used to support liver health and boost the immune system.
What it treats
- liver problems (hepatitis)
- digestive issues
- immune system support
How it works
Kalmegh contains compounds that may help promote liver function and enhance the body's defenses against illnesses.
Who it's for
Kalmegh may be suitable for adults looking for natural support for liver health and overall wellness.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About tricholine
Tricholine is a substance that helps support liver function and may aid in breaking down fats in the body.
What it treats
- liver disease
- fatty liver (steatosis)
How it works
Tricholine helps the liver process fats and supports overall liver health.
Who it's for
It is suitable for people dealing with liver-related issues or those needing help with fat metabolism.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: kalmegh
Kalmegh, also known as Andrographis paniculata, is a traditional medicinal herb used in various cultures, particularly in Ayurveda and Traditional Chinese Medicine. It is renowned for its anti-inflammatory, antiviral, and immune-modulating properties. The active compounds in kalmegh include andrographolide, which is primarily responsible for its pharmacological effects. Kalmegh is commonly used to treat fevers, respiratory infections, digestive disorders, and liver ailments.
Indications
- Fever
- Upper respiratory infections
- Inflammatory conditions
- Digestive disorders
- Hepatoprotection
- Viral infections
Dosage
Children: Dosing in children should be determined by a healthcare provider, considering the child's age
Adults: Recommended dosages of kalmegh vary based on the formulation used. It is important to refer to specific product guidelines or consult a healthcare professional for appropriate dosing.
Mechanism of action
Kalmegh exerts its therapeutic effects primarily through the modulation of the immune system and the inhibition of pro-inflammatory cytokines. Andrographolide interacts with various signaling pathways, including the NF-κB pathway, leading to a decrease in inflammation and an increase in immune response. It also has hepatoprotective properties, which help to safeguard liver function against toxins and oxidative stress.
Pharmacodynamics
Kalmegh demonstrates a range of pharmacodynamic effects, including anti-inflammatory, analgesic, and immunostimulant activities. The herb has shown efficacy in reducing the severity and duration of upper respiratory tract infections and has been studied for its potential benefits in managing conditions such as dengue fever and hepatitis. The pharmacological actions are attributed to the presence of diterpenoid lactones, with andrographolide being the most significant compound.
Pharmacokinetics
The pharmacokinetics of kalmegh can vary based on the formulation and method of administration. After oral administration, the absorption of andrographolide is relatively low, with bioavailability affected by first-pass metabolism. The compound is metabolized in the liver and excreted mainly through the bile. The half-life of andrographolide is not well-defined, but its effects can be prolonged due to its interaction with various biological pathways. Further studies are needed to fully elucidate the pharmacokinetic profile.
Adverse effects
- Gastrointestinal disturbances
- Allergic reactions
- Headache
- Fatigue
Precautions
- Use with caution in patients with liver disorders
- Consider potential allergic reactions in sensitive individuals
Pregnancy
Limited data available, use with caution and consult a healthcare provider.
Breast-feeding
Limited data available, consult a healthcare provider before use.
Storage
Store in a cool, dry place away from direct sunlight.
Formulations
- Dried leaf powder
- Extracts
- Capsules
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: tricholine
Tricholine is a choline salt, often used as a dietary supplement and is believed to play a role in various metabolic processes. It is a precursor to acetylcholine, a neurotransmitter that is critical for many bodily functions, including muscle movement and memory. Tricholine is sometimes utilized in the management of conditions related to choline deficiency and has been studied for its potential cognitive benefits.
Indications
- Choline deficiency
- Cognitive enhancement
- Neuromuscular disorders
- Lipid metabolism disorders
Dosage
Children: Refer to specific guidelines or consult a healthcare provider for appropriate dosing.
Adults: Refer to specific guidelines or consult a healthcare provider for appropriate dosing.
Mechanism of action
Tricholine acts primarily as a source of choline, which is necessary for the synthesis of phosphatidylcholine, a major component of cell membranes. It also serves as a precursor for the neurotransmitter acetylcholine. By increasing the availability of choline, tricholine may enhance cholinergic signaling, which can influence various physiological functions, including cognitive processing and muscle contraction.
Pharmacodynamics
Tricholine influences several physiological pathways, mainly related to neurotransmission and lipid metabolism. By enhancing choline availability, it supports the synthesis of acetylcholine, which is involved in neuromuscular transmission and cognitive functions. Additionally, it may contribute to the maintenance of cell membrane integrity and function due to its role in phospholipid synthesis.
Pharmacokinetics
Following oral administration, tricholine is absorbed in the gastrointestinal tract, where it is subsequently metabolized to choline. The bioavailability of choline can be affected by dietary factors and the presence of other nutrients. Choline is distributed widely throughout the body, crossing the blood-brain barrier to participate in central nervous system functions. Its elimination occurs primarily via metabolic pathways, with excretion through urine.
Adverse effects
- Gastrointestinal disturbances
- Nausea
- Diarrhea
- Allergic reactions
Precautions
- Use with caution in patients with gastrointestinal disorders
- Monitor for allergic reactions in sensitive individuals
Pregnancy
The safety of tricholine during pregnancy has not been established. Use only if clearly needed.
Breast-feeding
Limited information is available on the excretion of tricholine in human milk. Exercise caution and consult a healthcare provider.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Capsules
- Tablets
- Powder for oral solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.