What it does
Ulinastatin is a medication that helps to reduce inflammation and protect organs during certain medical conditions.
Commonly used for: acute pancreatitis, severe burns, organ transplant procedures
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:46:49 · updated 2026-07-26 11:37:18
About this medicine
Ulinastatin is a medication that helps to reduce inflammation and protect organs during certain medical conditions.
What it treats
- acute pancreatitis
- severe burns
- organ transplant procedures
How it works
It works by inhibiting enzymes that cause inflammation and tissue damage, helping the body to heal.
Who it's for
This medication is for patients experiencing severe inflammation or undergoing surgeries that may lead to organ stress.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: ulinastatin
Ulinastatin is a glycoprotein derived from human urine that exhibits protease inhibitor properties. It is primarily used for its anti-inflammatory and organ protective effects, particularly in conditions associated with acute inflammatory responses. Ulinastatin is often utilized in the management of acute pancreatitis, septic shock, and other critical illnesses where inflammation plays a significant role.
Indications
- Acute pancreatitis
- Septic shock
- Acute respiratory distress syndrome
- Acute kidney injury
- Multiple organ dysfunction syndrome
Dosage
Children: Paediatric dosing should be determined based on clinical guidelines and is not specified here. Refer to paediatric dosing references for appropriate recommendations.
Adults: Dosing in adults typically involves intravenous administration, with specific doses depending on the clinical scenario and guidelines. Refer to local protocols for exact dosing recommendations.
Mechanism of action
Ulinastatin functions by inhibiting various serine proteases, including trypsin and chymotrypsin, which are involved in inflammatory processes. By modulating the activity of these enzymes, ulinastatin reduces the production of pro-inflammatory cytokines and mitigates tissue damage associated with excessive inflammation. Additionally, it can influence the balance of the immune response, promoting a more regulated inflammatory process.
Pharmacodynamics
The pharmacodynamic effects of ulinastatin include anti-inflammatory, anti-apoptotic, and organ-protective properties. It has been shown to reduce the levels of inflammatory mediators and protect against organ dysfunction in settings of systemic inflammation. The drug may help stabilize endothelial function and improve microcirculation, contributing to its therapeutic effects in critically ill patients.
Pharmacokinetics
Ulinastatin is administered intravenously and has a rapid onset of action. The drug has a relatively short half-life, necessitating careful consideration of dosing intervals in clinical settings. It is primarily cleared from the body through renal excretion, emphasizing the importance of renal function in determining appropriate dosing in patients with compromised kidney function.
Adverse effects
- Allergic reactions
- Nausea
- Vomiting
- Diarrhea
- Rash
- Fever
Precautions
- Use with caution in patients with a history of allergic reactions to similar drugs.
- Monitor renal function during treatment.
Pregnancy
Ulinastatin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is limited data on its safety in pregnancy.
Breast-feeding
It is not known whether ulinastatin is excreted in human milk. Caution should be exercised when administering to nursing mothers.
Storage
Store at 2-8 degrees Celsius. Protect from light and freeze.
Formulations
- Injection solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.