UMICORT INJECTION
HYDROCORTSONE SODIUM SUCCINATE FOR INJECTION
What it does
Hydrocortisone is a medication used to reduce inflammation and treat various conditions related to the immune system.
Commonly used for: skin conditions (dermatitis), allergic reactions (allergies), inflammation (such as arthritis), adrenal insufficiency (Addison's disease)
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:35:08 · updated 2026-07-20 11:09:27
About this medicine
Hydrocortisone is a medication used to reduce inflammation and treat various conditions related to the immune system.
What it treats
- skin conditions (dermatitis)
- allergic reactions (allergies)
- inflammation (such as arthritis)
- adrenal insufficiency (Addison's disease)
How it works
Hydrocortisone works by mimicking cortisol, a hormone that helps to reduce inflammation and suppress the immune response.
Who it's for
It is for people who need relief from inflammation or have hormone deficiencies.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: hydrocortsone
Hydrocortisone is a corticosteroid medication used to treat various inflammatory and autoimmune conditions. It mimics the action of cortisol, a natural hormone produced by the adrenal glands, and exhibits anti-inflammatory, immunosuppressive, and antiproliferative effects. Hydrocortisone is commonly used for conditions such as adrenal insufficiency, allergic reactions, skin disorders, and certain types of arthritis.
Indications
- Adrenal insufficiency
- Allergic reactions
- Asthma exacerbations
- Chronic inflammatory conditions
- Skin disorders (e.g., eczema, dermatitis)
- Rheumatoid arthritis
- Systemic lupus erythematosus
Dosage
Children: Refer to BNF for Children for appropriate dosing based on the child's age, weight, and condition.
Adults: Refer to BNF for specific dosing guidelines based on the condition being treated.
Mechanism of action
Hydrocortisone acts by binding to the glucocorticoid receptor, leading to the activation of gene transcription that produces anti-inflammatory proteins and inhibits the expression of pro-inflammatory genes. This results in decreased production of inflammatory mediators, suppression of the immune response, and modulation of metabolic processes.
Pharmacodynamics
The pharmacodynamic effects of hydrocortisone include the reduction of inflammation and swelling, modulation of immune responses, and regulation of carbohydrate, protein, and fat metabolism. Its anti-inflammatory properties are primarily due to the inhibition of phospholipase A2 and the suppression of the synthesis of prostaglandins and leukotrienes, potent mediators of inflammation.
Pharmacokinetics
Hydrocortisone is rapidly absorbed when administered orally, with peak plasma concentrations occurring within 1 to 2 hours. It is extensively metabolized in the liver, primarily through conjugation and reduction processes, and has a half-life of approximately 1.5 to 2 hours. The drug is excreted via the kidneys, primarily as metabolites. Its effects can last longer than its half-life due to the nature of its action on gene expression.
Contra-indications
- Systemic fungal infections
- Hypersensitivity to hydrocortisone or any of its components
- Live vaccines in immunocompromised patients
Adverse effects
- Increased risk of infections
- Cushing's syndrome
- Hypertension
- Hyperglycemia
- Fluid retention
- Weight gain
- Mood changes
- Gastrointestinal disturbances
- Osteoporosis
Interactions
- Non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal side effects
- Anticoagulants may have altered effects when used with corticosteroids
- Phenytoin and barbiturates may reduce the effect of hydrocortisone
- Live vaccines may be less effective and increase the risk of infection
Precautions
- Use with caution in patients with diabetes mellitus
- Monitor for signs of infection during therapy
- Gradual withdrawal is recommended after prolonged use to avoid adrenal insufficiency
- Consider potential impact on growth in pediatric patients
Pregnancy
Hydrocortisone is classified as pregnancy category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Hydrocortisone is excreted in breast milk, and caution should be exercised when administering to nursing mothers.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
Formulations
- Oral tablets
- Topical cream
- Injectable solution
- Rectal foam
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.