What it does
Povidone-iodide is a topical antiseptic used to disinfect and prevent infections in wounds and skin.
Commonly used for: skin infections, cuts and abrasions, pre-operative skin preparation
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:43 · updated 2026-09-29 04:33:06
About this medicine
Povidone-iodide is a topical antiseptic used to disinfect and prevent infections in wounds and skin.
What it treats
- skin infections
- cuts and abrasions
- pre-operative skin preparation
How it works
It works by killing bacteria, viruses, and fungi on the skin.
Who it's for
It is suitable for anyone needing to clean wounds or prepare skin for surgery.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: povidoneiodide
Povidone-iodine is an antiseptic solution commonly used for skin disinfection before surgery, as well as for minor wounds and infections. It is a complex of iodine and povidone, allowing for a slower release of iodine, which provides antiseptic activity while minimizing skin irritation. It is effective against bacteria, viruses, fungi, and protozoa.
Indications
- Preoperative skin disinfection
- Treatment of minor cuts and abrasions
- Management of infected wounds
- Disinfection of mucous membranes
- Skin antisepsis in healthcare settings
Dosage
Children: Refer to the BNF for Children for appropriate dosing guidelines based on age and condition.
Adults: Apply to the affected area as needed, ensuring complete coverage. The concentration may vary based on the application site and severity of infection.
Mechanism of action
Povidone-iodine releases free iodine upon contact with the skin or mucous membranes. The free iodine penetrates microbial cell walls, disrupting protein synthesis and causing cell death. This broad-spectrum antimicrobial action makes it effective against a wide range of pathogens.
Pharmacodynamics
Povidone-iodine exhibits bactericidal, virucidal, and fungicidal properties. The concentration of iodine determines its antimicrobial effectiveness, with higher concentrations providing faster action against microorganisms. It also has a residual antimicrobial effect, which can help prevent infection during surgical procedures.
Pharmacokinetics
Povidone-iodine is primarily used topically and is not significantly absorbed through intact skin. When applied to damaged skin or mucous membranes, minimal systemic absorption may occur. The iodine released from povidone-iodine is excreted primarily through the kidneys. Its half-life in systemic circulation is not well defined due to its local use.
Contra-indications
- Hypersensitivity to povidone-iodine or any of its components
- Thyroid dysfunction
- Severe renal impairment
Adverse effects
- Skin irritation or rash
- Burning sensation at the application site
- Allergic reactions including anaphylaxis
- Thyroid dysfunction (hyperthyroidism or hypothyroidism)
- Staining of skin or mucous membranes
Interactions
- May interfere with thyroid function tests
- Potential interaction with other antiseptics or topical agents
Precautions
- Use with caution in patients with renal impairment
- Avoid use on large wounds or deep puncture wounds
- Not for prolonged use due to potential systemic absorption of iodine
Pregnancy
Povidone-iodine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a healthcare professional before use.
Breast-feeding
Povidone-iodine should be used with caution during breastfeeding. It is advisable to consult a healthcare professional before use.
Storage
Store at room temperature, away from direct sunlight and moisture. Keep out of reach of children.
Formulations
- Topical solution
- Ointment
- Surgical scrub
- Swabs or pads soaked in povidone-iodine
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.