VEDROX 500 CAPSULES
CEFADROXILCAPSULES USP 500 MG
What it does
Cefadroxil capsules are antibiotics used to treat bacterial infections.
Commonly used for: skin infections, throat infections (pharyngitis), urinary tract infections (UTIs), respiratory infections
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 22:08:55 · updated 2026-03-23 04:54:04
About this medicine
Cefadroxil capsules are antibiotics used to treat bacterial infections.
What it treats
- skin infections
- throat infections (pharyngitis)
- urinary tract infections (UTIs)
- respiratory infections
How it works
Cefadroxil works by killing bacteria or stopping their growth, helping your body to fight the infection.
Who it's for
Cefadroxil is for adults and children who have certain bacterial infections.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: cefadroxilcapsules
Cefadroxil is a first-generation cephalosporin antibiotic used to treat a variety of bacterial infections. It is effective against both Gram-positive and some Gram-negative bacteria. As an oral agent, it is commonly prescribed for skin infections, urinary tract infections, and respiratory tract infections. Its stability against certain beta-lactamases makes it effective against some resistant strains of bacteria.
Indications
- Skin and soft tissue infections
- Urinary tract infections
- Respiratory tract infections
- Bone infections
- Otitis media
Dosage
Children: Refer to BNF for Children for specific dosing guidelines based on the child's age and weight.
Adults: Refer to BNF for specific dosing guidelines based on the type and severity of the infection.
Mechanism of action
Cefadroxil acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, leading to the inhibition of peptidoglycan cross-linking. This disruption of cell wall integrity results in cell lysis and death, particularly in actively growing bacteria.
Pharmacodynamics
Cefadroxil demonstrates time-dependent antibacterial activity, meaning its effectiveness is related to the duration of time the drug concentration remains above the minimum inhibitory concentration (MIC) for the targeted bacteria. It has a broad spectrum of activity, particularly against Streptococcus and Staphylococcus species, as well as Escherichia coli and Proteus mirabilis.
Pharmacokinetics
Cefadroxil is rapidly absorbed after oral administration, with peak plasma concentrations occurring approximately 1 to 2 hours post-dose. It has a bioavailability of about 90%. The drug is primarily eliminated by the kidneys, with about 80% of the administered dose excreted unchanged in the urine. The half-life is approximately 1 hour, but this can be longer in patients with renal impairment.
Contra-indications
- Hypersensitivity to cefadroxil or other cephalosporin antibiotics
- History of severe allergic reactions to penicillins
Adverse effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Urticaria
- Anaphylaxis
- Clostridium difficile-associated diarrhea
Interactions
- Probenecid may decrease the renal excretion of cefadroxil, increasing its plasma concentration
- Anticoagulants may enhance the anticoagulant effect when used with cefadroxil
Precautions
- Use with caution in patients with renal impairment
- Monitor for signs of gastrointestinal disease, particularly colitis
- Assess for potential allergic reactions, especially in patients with a history of penicillin allergy
Pregnancy
Cefadroxil is categorized as Pregnancy Category B. Animal reproduction studies have not demonstrated a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women.
Breast-feeding
Cefadroxil is excreted in breast milk. Caution should be exercised when administering to nursing mothers.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Cefadroxil 500 mg capsules
- Cefadroxil 1 g capsules
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.