Vit-B-denk tablets
Thaimine Hydrochloride BP 100 mg
What it does
Thiamine is a vitamin that helps the body convert food into energy and supports nerve function.
Commonly used for: beriberi (thiamine deficiency), Wernicke-Korsakoff syndrome, certain metabolic disorders
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Sourcing - Kenya onlyRegistration & product details
Source: Zambia Medicines Regulatory Authority · fetched 2026-03-12 00:03:35 · updated 2026-05-22 02:42:51
About this medicine
Thiamine is a vitamin that helps the body convert food into energy and supports nerve function.
What it treats
- beriberi (thiamine deficiency)
- Wernicke-Korsakoff syndrome
- certain metabolic disorders
How it works
Thiamine plays a crucial role in breaking down carbohydrates, which provides energy for the body's cells.
Who it's for
Thiamine is for people who have a deficiency or need extra support for their metabolism and nerve health.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: thaimine
Thiamine, also known as vitamin B1, is a water-soluble vitamin that plays a crucial role in carbohydrate metabolism and is essential for the biosynthesis of neurotransmitters. It is vital for proper cellular function, particularly in the nervous system and muscles, and is used therapeutically to prevent and treat thiamine deficiency, which can lead to conditions such as Wernicke's encephalopathy and beriberi.
Indications
- Thiamine deficiency
- Wernicke's encephalopathy
- Beriberi (wet and dry)
- Peripheral neuropathy
- Alcoholic neuropathy
- Supportive treatment in metabolic disorders
Dosage
Children: Refer to BNF for Children for specific dosing guidelines.
Adults: Refer to BNF for specific dosing guidelines.
Mechanism of action
Thiamine acts as a coenzyme in the decarboxylation of alpha-keto acids and the hexose monophosphate shunt. It is converted into thiamine pyrophosphate (TPP), which is essential for the metabolism of carbohydrates and amino acids, aiding in the conversion of pyruvate to acetyl-CoA and playing a role in the pentose phosphate pathway, which is crucial for nucleotide synthesis.
Pharmacodynamics
Thiamine is involved in energy metabolism, specifically in carbohydrate metabolism. It enhances the metabolism of carbohydrates into glucose and contributes to the functioning of the nervous system by supporting neurotransmitter synthesis. Its deficiency can impair cognitive function and lead to neurological symptoms.
Pharmacokinetics
Thiamine is absorbed in the intestines via active transport and passive diffusion. It is distributed throughout the body, particularly in the liver, heart, and brain. The elimination half-life varies but is generally short, with excess thiamine being excreted in the urine. Thiamine is not stored in large quantities, hence regular dietary intake is necessary.
Adverse effects
- Allergic reactions
- Hypersensitivity
- Nausea
- Vomiting
- Diarrhea
Precautions
- Use with caution in patients with renal impairment
- Monitor for signs of allergic reactions
- Consider dietary sources of thiamine in patients with malnutrition
Pregnancy
Thiamine is generally considered safe during pregnancy; however, always consult a healthcare provider for individual advice.
Breast-feeding
Thiamine is excreted in breast milk and is considered safe; however, consult a healthcare provider for individual advice.
Storage
Store in a cool, dry place away from light. Keep out of reach of children.
Formulations
- Oral tablets
- Injectable solutions
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.