WONDER POWDER COMBINATION PRODUCT POWDER
MCHAPE(GINGER,TURMERIC,GARLIC,NEEM,CINNAMON,MORINGA)
What it does
Mchape is a medication used to treat various health conditions. Please consult with a healthcare provider for more information.
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:43 · updated 2026-09-29 04:33:06
About this medicine
Mchape is a medication used to treat various health conditions. Please consult with a healthcare provider for more information.
How it works
The exact mechanism of how mchape works is not specified.
Who it's for
Mchape may be prescribed for patients with specific health issues as determined by a healthcare professional.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: mchape
Mchape, commonly known as Mefloquine, is an antimalarial drug used for the prevention and treatment of malaria, particularly in areas with known chloroquine-resistant strains of Plasmodium falciparum. It is a member of the 4-quinoline methanol class of antimalarials and helps to reduce the incidence of malaria in travelers to endemic regions.
Indications
- Prophylaxis of malaria in travelers to endemic areas
- Treatment of uncomplicated malaria caused by Plasmodium falciparum
- Alternative treatment for chloroquine-resistant malaria
Dosage
Children: Refer to BNF for Children for appropriate pediatric dosing recommendations.
Adults: Refer to BNF for specific dosing guidelines, as dosing may vary based on indication and patient factors.
Mechanism of action
Mefloquine's exact mechanism of action is not fully understood, but it is believed to interfere with the heme polymerization pathway. During the intraerythrocytic stage of the malaria life cycle, it inhibits the conversion of toxic heme to non-toxic hemozoin, leading to the accumulation of toxic heme within the parasite, which ultimately results in its death.
Pharmacodynamics
Mefloquine exerts its antimalarial effects by disrupting the parasite's ability to metabolize hemoglobin and detoxify heme, leading to increased oxidative stress and cellular damage within the parasite. It has a long half-life, allowing for once-weekly dosing in prophylaxis and once-daily dosing in treatment, making it convenient for travelers and patients.
Pharmacokinetics
Mefloquine is well-absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 24 hours of oral administration. It has a large volume of distribution and is extensively protein-bound, primarily to albumin. The drug undergoes hepatic metabolism, primarily by cytochrome P450 enzymes, and is excreted in the bile and urine. The elimination half-life ranges from 14 to 30 days, which supports its use in both treatment and prophylaxis.
Pregnancy
The safety of mchape during pregnancy has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
There is limited information on the excretion of mchape in human milk. Caution should be exercised when administering to breastfeeding women.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.