ZI-AD 20 MG TABLET

Indications

• Zinc deficiency
• Wound healing
• Diarrhea in children
• Acne
• Common cold
• Immune support

Dosage

Children: Refer to the BNF for Children for specific dosing guidelines based on the child's age, weight, and condition.

Adults: Refer to the BNF for specific dosing guidelines based on the condition being treated and the formulation used.

Mechanism of action

Zinc sulfate provides zinc ions (Zn²⁺) that are essential for numerous biological processes. Zinc acts as a cofactor for many enzymes, facilitating various biochemical reactions. It also plays a role in modulating immune responses, promoting the activity of T-lymphocytes, and influencing the production of cytokines. Furthermore, zinc is vital for maintaining structural integrity in proteins and cell membranes.

Pharmacodynamics

The pharmacodynamic effects of zinc sulfate primarily relate to its role in enzymatic functions and immune modulation. Zinc deficiency can impair immune function, leading to increased susceptibility to infections. Supplementation with zinc sulfate can enhance immune responses, improve wound healing, and contribute to overall health by restoring normal zinc levels in the body. Additionally, zinc has antioxidant properties, helping to combat oxidative stress.

Pharmacokinetics

Zinc sulfate is absorbed in the gastrointestinal tract, with an absorption rate that can vary based on the presence of food and other dietary factors. Peak plasma concentrations are typically reached within 2 to 3 hours after oral administration. Zinc is distributed throughout the body, particularly in skeletal muscle, bone, and the liver. The elimination half-life of zinc from the body is approximately 2 to 3 days, and it is primarily excreted through the kidneys and gastrointestinal tract.

Contra-indications

• Hypersensitivity to zinc sulfate or any component of the formulation
• Severe renal impairment

Adverse effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Metallic taste
• Headache
• Drowsiness
• Fatigue

Interactions

• Antibiotics (e.g., tetracyclines and quinolones) - zinc may impair absorption
• Copper supplements - excessive zinc can lead to copper deficiency

Precautions

• Use with caution in patients with renal impairment
• Avoid high doses in patients with conditions requiring low zinc intake
• Monitor for signs of zinc toxicity, especially with prolonged use

Pregnancy

Zinc is essential during pregnancy for proper fetal development, but supplementation should be done under medical guidance to avoid excessive intake.

Breast-feeding

Zinc is secreted in breast milk, and supplementation should be discussed with a healthcare provider to ensure adequate maternal and infant intake.

Storage

Store in a cool, dry place away from light. Keep out of reach of children.

Formulations

• Oral tablets
• Oral solution
• Effervescent tablets
• Syrup