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Tildiprosin
What it does
Tildiprosin is a medication used to treat certain infections in animals.
Commonly used for: bacterial infections, respiratory infections
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: South African Health Products Regulatory Authority · fetched 2026-04-15 21:18:22 · updated 2026-10-21 04:01:07
About this medicine
Tildiprosin is a medication used to treat certain infections in animals.
What it treats
- bacterial infections
- respiratory infections
How it works
Tildiprosin works by stopping the growth of bacteria, helping the body fight off infections.
Who it's for
This medication is typically used for animals that are suffering from specific bacterial infections.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: tildiprosin
Tildiprosin is a novel macrolide antibiotic that demonstrates efficacy against a range of gram-positive and some gram-negative bacteria. It is primarily utilized in veterinary medicine, particularly for the treatment of respiratory diseases in livestock. Its unique structure and mechanism allow it to inhibit bacterial protein synthesis, making it effective in combating infections.
Indications
- Bacterial infections
- Respiratory disease in livestock
- Bacterial pneumonia
- Skin infections
Dosage
Children: Refer to the specific product information for pediatric dosing recommendations.
Adults: Refer to the specific product information for dosing recommendations.
Mechanism of action
Tildiprosin exerts its antibacterial effects by binding to the 50S subunit of the bacterial ribosome, inhibiting protein synthesis. This action disrupts the process of translation, preventing the synthesis of essential proteins needed for bacterial growth and replication.
Pharmacodynamics
Tildiprosin has a broad spectrum of activity, particularly against anaerobic and certain aerobic bacteria. It shows bacteriostatic properties, meaning it inhibits the growth of bacteria rather than killing them outright. Its efficacy may also be enhanced in the presence of inflammatory conditions, which can affect drug distribution and bacterial susceptibility.
Pharmacokinetics
Tildiprosin is absorbed well after administration and achieves therapeutic concentrations in tissues, particularly in the lungs, making it suitable for respiratory infections. It has a relatively long half-life, allowing for less frequent dosing. The drug is primarily metabolized in the liver and excreted via the bile, with minimal renal excretion.
Adverse effects
- Diarrhea
- Vomiting
- Decreased appetite
- Lethargy
- Abdominal pain
Precautions
- Use with caution in animals with liver or kidney impairment.
- Monitor for signs of hypersensitivity.
- Evaluate the risk versus benefit in pregnant or lactating animals.
Pregnancy
Safety during pregnancy has not been established. Use only if benefits outweigh risks.
Breast-feeding
Safety during breastfeeding has not been established. Use with caution.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Injectable solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.