What it does
Fluticasone is a medication often used to relieve symptoms of allergies and asthma. It helps reduce inflammation in the airways.
Commonly used for: allergic rhinitis (hay fever), asthma, chronic obstructive pulmonary disease (COPD)
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:13:05 · updated 2026-07-20 08:56:14
About this medicine
Fluticasone is a medication often used to relieve symptoms of allergies and asthma. It helps reduce inflammation in the airways.
What it treats
- allergic rhinitis (hay fever)
- asthma
- chronic obstructive pulmonary disease (COPD)
How it works
Fluticasone works by decreasing inflammation in the airways, making it easier to breathe and reducing allergy symptoms.
Who it's for
It is suitable for people suffering from asthma, allergies, or COPD.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: fluticanose
Fluticasone is a synthetic corticosteroid used primarily for its anti-inflammatory and immunosuppressive properties. It is commonly administered via inhalation, nasal spray, or topical formulations to manage conditions such as asthma, allergic rhinitis, and skin disorders. The drug acts by modulating the immune response and reducing inflammation in affected tissues, making it effective for managing chronic inflammatory conditions.
Indications
- Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
- Allergic Rhinitis
- Eczema
- Psoriasis
Dosage
Children: Refer to the BNF for Children for specific dosing recommendations based on age and weight.
Adults: Refer to the BNF for specific dosing guidelines based on the formulation and condition being treated.
Mechanism of action
Fluticasone works by binding to the glucocorticoid receptor, leading to the regulation of gene expression that affects the synthesis of anti-inflammatory proteins and the inhibition of pro-inflammatory cytokines. This results in decreased inflammation, suppression of the immune response, and reduced mucous production, which is beneficial in treating asthma and allergic reactions.
Pharmacodynamics
Fluticasone exhibits potent anti-inflammatory effects and is significantly more effective than many other corticosteroids. It reduces the recruitment of eosinophils and other inflammatory cells to sites of inflammation, leading to lower levels of inflammatory mediators. Its clinical effect is observed in the reduction of airway hyperresponsiveness and improvement in lung function in asthmatic patients.
Pharmacokinetics
Fluticasone is well-absorbed when administered by inhalation or nasal route, but it undergoes extensive first-pass metabolism in the liver, which limits systemic exposure. The elimination half-life of fluticasone is approximately 8 hours. The drug is primarily excreted as metabolites in the feces and urine, with a low potential for systemic side effects due to its high local activity and low bioavailability.
Contra-indications
- Hypersensitivity to fluticasone or any of its components
- Active or untreated infections
- Severe hypersensitivity reactions
Adverse effects
- Nasal irritation or burning
- Headache
- Epistaxis (nosebleeds)
- Pharyngitis
- Cough
- Systemic corticosteroid effects with prolonged use
Interactions
- CYP3A4 inhibitors (e.g., ritonavir, ketoconazole) may increase fluticasone levels
- Corticosteroids may interact with other medications that affect the immune system
Precautions
- Use with caution in patients with active or quiescent tuberculosis infections
- Monitor for signs of adrenal suppression or Cushing's syndrome with prolonged use
- Patients with a history of glaucoma or cataracts should be monitored
Pregnancy
Fluticasone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Fluticasone is excreted in breast milk; caution is advised when administering to nursing women.
Storage
Store at room temperature, away from light and moisture. Do not freeze.
Formulations
- Nasal spray
- Inhalation aerosol
- Topical cream
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.