bosentan brands
2 registered brands containing bosentan in Zambia.
2D structure
Bosentan
PubChem CID 104865Molecular formula: C27H29N5O6S
Endothelin-1 (ET-1) is a neurohormone, the effects of which are mediated by binding to ET<sub>A</sub> and ET<sub>B</sub> receptors in the endothelium and vascular smooth muscle. It displays a slightly higher affinity towards ET<sub>A</sub> receptors than ET<sub>B</sub> receptors. ET-1 concentrations are elevated in plasma and lung tissue of patients with pulmonary arterial hypertension, suggesting a pathogenic role for ET-1 in this disease. Bosentan is a specific and competitive antagonist at endothelin receptor types ET<sub>A</sub> and ET<sub>B</sub>.
Source: PubChem (NCBI) ยท compound 104865
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| Product | Manufacturer | Status | Country |
|---|---|---|---|
| Pulmofirst 125 tablets Tablet Uncoated |
Msn Laboratories | Registered/Compliant | Zambia |
| Pulmofirst 62.5 tablets Tablet Uncoated |
Msn Laboratories | Registered/Compliant | Zambia |