capsaicin brands

8 registered brands containing capsaicin in Kenya.

2D structure

Capsaicin

Molecular formula: C18H27NO3

Capsaicin has been shown to reduce the amount of substance P associated with inflammation - however this is not believed to be its main mechanism in the relief of pain. Capsaicin's mechanism of action is attributed to "defunctionalization" of nociceptor fibers by inducing a topical hypersensitivity reaction on the skin. This alteration in pain mechanisms is due to many of the following: temporary loss of membrane potential, inability to transport neurotrophic factors leading to altered phenotype, and reversible retraction of epidermal and dermal nerve fiber terminals. Capsaicin, the pungent constituent of chili peppers, represents the paradigm for the capsaicinoids or vanilloids, a family of compounds shown to stimulate and then desensitize specific subpopulations of sensory receptors, including C-polymodal nociceptors, A-delta mechanoheat nociceptors and warm receptors of the skin, as well as enteroceptors of thin afferent fibers. ... ... In rats desensitized by intraperitoneal (ip) capsaicin (i.e., abdominal non-systemic desensitization), mainly the first but not the later fever phases were reduced. The postprandial hyperthermia to intragastric injection of BaSO4 suspension was attenuated by either ip or perineural capsaicin treatment. ... Heat and protons as well as capsaicin activate VR1 to induce the influx of cations, particularly Ca2+ and Na+ ions. Characteristic effects of capsaicin are the induction of a burning sensation after acute administration and the desensitization of sensory neurons after large doses and prolonged administration. ... Capsaicin alters several visceral functions. ... Capsaicin affects thermoregulation after intra-hypothalamic injection and releases glutamate from the hypothalamus and cerebral cortex slices, while VR1-like immunoreactivity is not apparent in these regions. ... 0.4 and 4 uM of capsaicin produced a significant tonic block on voltage-activated Na+ current (I(Na)) evoked by a depolarizing step to -40 mV from a holding potential of -100 mV (49 +/- 7% n=11, p<0.05 and 72 +/- 13% n=4, p<0.05 respectively). ... Capsaicin slowed the time decay of inactivation of I(Na), and increased the time constant of the recovery of inactivation. Capsaicin and tetrodotoxin (TTX) depressed contractility of isolated electrically driven left rat atria, being the depression of maximal velocity of force development (dF/dt(max)) with respect to control values of 19 +/- 3% at 1 uM of capsaicin and 22 +/- 2% at 1 uM of TTX. For more Mechanism of Action (Complete) data for CAPSAICIN (8 total), please visit the HSDB record page.

NADH to cytochrome bo oxidase electron transfer IBioCyc NADH to cytochrome bd oxidase electron transfer IBioCyc NADH to cytochrome bo oxidase electron transfer IBioCyc NADH to cytochrome bd oxidase electron transfer IBioCyc

Source: PubChem (NCBI) · compound 1548943

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Product	Manufacturer	Status	Country
CAPSIFENAC GEL CAPSAICIN USP 0.025% W/W (AS CAPSICUM OLEORESIN) DICLOFENAC DIETHYLAMINE BP 1.160% W/W LEVOMENTHOL BP 1.000% W/W METHYL SALICYLATE BP 3.000% W/W	Wessex Pharmaceuticals	Registered	Kenya
Capsifenac gel Gel	Prisma Pharma FZE	Retained	Kenya
ELAXIC FAST GEL DICLOFENAC DIETHYLAMINE BP1.16% EQUIVALENT TO DICLOFENAC SODIUM 1% W/W TUBE, VIRGIN LINSEED OIL 3%W/W TUBE,LEVOMENTHOL 5%W/W TUBE, METHYL SALICYLATE 10% W/W,CAPSAICIN0.025% W/W TUBE	Viva Healthcare	Registered	Kenya
ETO MR GEL ACECLOFENAC BP 1.5%W/W, THIOCOLCHICOSIDE BP0.125%W/W, LINSEED OIL BP 3%W/W, MENTHOL BP 5%W/W, METHYL SALICYLATE BP 10%W/W AND CAPSAICIN USP 0.01%W/W.	Eastleigh Pharmaceutuical Limited	Registered	Kenya
FOPYN FAST GEL DICLOFENAC DIETHYLAMINE BP 1.16 % W/W EQUIVALENT TO DICLOFENAC SODIUM: 1.0 % W/W VIRGIN LINSEED OIL BP : 3.0 % W/W LEVOMENTHOL BP : 5.0 0 % W/W METHYL SALICYLATE BP : 10.00 % W/W CAPSAICIN USP : 0.025% W/W	Signature Healthcare	Registered	Kenya
LYSODOL GEL - ACECLOFENAC BP 1.5% W/W -OLEUM LINI (CONTAINING PREDOMINANTLY ALPHA LINOLENIC ACID) 3% W/W - METHYL SALICYLATE BP 10 % W/W - CAPSAICIN USP 0.01% W/W - MENTHOL USP 5 % W/W	Galaxy Pharmaceutical	Registered	Kenya
MYONAC GEL ACECLOFENAC BP 1.5%W/W METHYL SALICYLATE BP 10%W/W VIRGIN LINSEED OIL BP 3%W/W CAPSAICIN USP 0.01%W/W MENTHOL USP 5%W/W	Win-pharma	Registered	Kenya
POWER HEAT PLUS METHYL SALICYLATE BP 10.00 % W/W, DICLOFENAC DIETHYLAMINE BP 1.16 %W/W EQ. TO DICLOFENAC SODIUM BP 1.00 % W/W ,LINSEED OIL BP 3.00 %,MENTHOL BP 5.00 % W/W & CAPSAICIN USP 0.025 % W/W	Syner-med Pharmaceuticalsltd	Registered	Kenya