Almagate, 1.5g

Indications

• Gastric hyperacidity
• Peptic ulcer disease
• Gastroesophageal reflux disease (GERD)
• Dyspepsia

Dosage

Children: Refer to the BNF for Children for specific paediatric dosing recommendations.

Adults: Refer to the BNF for specific adult dosing recommendations.

Mechanism of action

Almagate acts as a buffering agent, reacting with hydrochloric acid in the stomach to form aluminum chloride, magnesium chloride, and water. This reaction reduces gastric acidity, leading to an increase in gastric pH, which helps to relieve symptoms associated with acid overproduction.

Pharmacodynamics

The pharmacodynamics of almagate involve its capacity to neutralize gastric acid, which in turn decreases pepsin activity and promotes mucosal healing. By increasing gastric pH, it provides symptomatic relief from heartburn, indigestion, and acid reflux. The onset of action is typically rapid, providing quick relief from discomfort.

Pharmacokinetics

Almagate is not significantly absorbed into the systemic circulation, as it primarily acts locally in the gastrointestinal tract. Its effects are dose-dependent, and the duration of action may vary based on the formulation and individual patient factors. Excretion of aluminum and magnesium occurs mainly through the feces, with minimal renal involvement due to low systemic absorption.

Pregnancy

Almagate is generally considered safe during pregnancy, but it is best to consult with a healthcare provider before use.

Breast-feeding

Almagate is believed to be safe during breastfeeding, but consulting a healthcare provider is recommended.

Storage

Store at room temperature, away from moisture and direct sunlight.

Formulations

• Tablets
• Suspension