What it does
Polysorbate is a substance often used as an emulsifier, helping to mix ingredients that usually don't blend well together in medications and food products.
Commonly used for: used in various medications and food products to stabilize mixtures
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Sourcing - Kenya onlyRegistration & product details
Source: Botswana Medicines Regulatory Authority · fetched 2026-04-15 20:43:07 · updated 2026-10-20 04:32:24
About this medicine
Polysorbate is a substance often used as an emulsifier, helping to mix ingredients that usually don't blend well together in medications and food products.
What it treats
- used in various medications and food products to stabilize mixtures
How it works
It helps to keep ingredients mixed evenly, preventing separation and improving texture.
Who it's for
Suitable for individuals who need products containing polysorbate for various health or dietary reasons.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: polysorbate
Polysorbate is a non-ionic surfactant and emulsifier used in various pharmaceutical formulations. It is derived from sorbitol and fatty acids and is known for its capacity to enhance the solubility of hydrophobic compounds in aqueous solutions. Polysorbate is commonly utilized in the preparation of oral, parenteral, and topical pharmaceutical products, as well as in food and cosmetic industries.
Indications
- Emulsifying agent in drug formulations
- Stabilizer for parenteral preparations
- Solubilizer for hydrophobic drug compounds
- Ingredient in topical formulations
Dosage
Children: Refer to specific product guidelines, as dosing varies based on formulation and intended use.
Adults: Refer to specific product guidelines, as dosing varies based on formulation and intended use.
Mechanism of action
Polysorbate functions primarily as an emulsifying agent. It reduces the surface tension between immiscible liquids, allowing them to mix more easily. This property is particularly useful in stabilizing emulsions and suspensions, facilitating the delivery of active pharmaceutical ingredients in various formulations.
Pharmacodynamics
Polysorbate does not exert pharmacological effects in the traditional sense, as it does not bind to specific receptors to elicit a physiological response. Instead, it plays a crucial role in modifying the physical properties of drug formulations, thereby enhancing drug delivery and absorption. Its ability to solubilize drugs enhances their bioavailability, particularly for poorly soluble compounds.
Pharmacokinetics
Polysorbate is generally considered to be non-toxic and is not absorbed to a significant extent when administered orally. It is metabolized by the liver and excreted primarily through the gastrointestinal tract. The pharmacokinetic profile may vary depending on the route of administration and the specific formulation in which it is used.
Adverse effects
- Allergic reactions
- Skin irritation
- Gastrointestinal disturbances
Precautions
- Use cautiously in patients with known allergies to polysorbates or related compounds
- Monitor for allergic reactions in susceptible individuals
Pregnancy
Polysorbate is generally considered safe for use during pregnancy, but consult with a healthcare provider for specific cases.
Breast-feeding
Polysorbate is considered safe during breastfeeding, but consult with a healthcare provider for individual advice.
Storage
Store at room temperature, away from direct sunlight and moisture.
Formulations
- Polysorbate 20
- Polysorbate 80
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.