Bravecto 250 Tablets

Indications

• Flea infestation
• Tick infestation
• Prevention of flea and tick infestations

Dosage

Children: Refer to the BNF for Children for appropriate paediatric dosing information regarding fluralaner.

Adults: Refer to the BNF for specific adult dosing guidelines, as fluralaner dosing may vary based on the weight of the animal and the formulation used.

Mechanism of action

Fluralaner acts as a potent inhibitor of the insect GABA-gated chloride channels and the glutamate-gated chloride channels. By blocking these channels, fluralaner disrupts the normal function of the nervous system in parasites, leading to paralysis and death of the flea and tick species.

Pharmacodynamics

Fluralaner exhibits a high level of selectivity for the target channels found in arthropods, resulting in reduced toxicity to mammals. Its efficacy against fleas and ticks is attributed to its ability to cause rapid paralysis and mortality in these parasites upon exposure.

Pharmacokinetics

Fluralaner is absorbed rapidly after oral administration, reaching peak plasma concentrations within 1-2 days. It has a high volume of distribution and is extensively metabolized in the liver. The elimination half-life ranges from several days to weeks, depending on the species treated. Fluralaner is excreted primarily in feces, with minimal renal excretion.

Adverse effects

• Vomiting
• Diarrhea
• Anorexia
• Lethargy
• Hypersensitivity reactions

Precautions

• Use with caution in animals with a history of seizures
• Not recommended for use in breeding, pregnant, or lactating animals

Pregnancy

Safety during pregnancy has not been established.

Breast-feeding

Safety during lactation has not been established.

Storage

Store at room temperature, protect from moisture and light.

Formulations

• Oral solution
• Topical solution