CALDOB CAPSULES
CALCIUM DOBESYLATE MONOHYDRATE BP 500 MG CAPSULES
What it does
Dobesylate is a medication often used to improve blood circulation and relieve symptoms related to poor blood flow.
Commonly used for: poor circulation, chronic venous insufficiency
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:11:44 · updated 2026-07-20 08:54:53
About this medicine
Dobesylate is a medication often used to improve blood circulation and relieve symptoms related to poor blood flow.
What it treats
- poor circulation
- chronic venous insufficiency
How it works
Dobesylate helps to enhance blood flow and reduce swelling in the veins.
Who it's for
It is suitable for adults experiencing issues with blood circulation.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: dobesylate
Dobesylate is a synthetic compound that acts as a venotonic agent, primarily used to improve venous tone and reduce symptoms related to venous insufficiency. It is commonly employed in the management of conditions such as chronic venous disease and hemorrhoids.
Indications
- Chronic venous insufficiency
- Varicose veins
- Hemorrhoids
- Post-thrombotic syndrome
- Leg edema
Dosage
Children: Refer to prescribing guidelines for specific dosing information.
Adults: Refer to prescribing guidelines for specific dosing information.
Mechanism of action
Dobesylate exerts its effects by stabilizing capillary walls and enhancing venous tone. It inhibits the leakage of fluids and proteins from capillaries, thereby reducing edema and inflammation. The exact molecular pathways involve modulation of the endothelial cells and extracellular matrix in blood vessels.
Pharmacodynamics
Dobesylate improves venous return and decreases venous stasis. It has been shown to enhance lymphatic drainage and reduce symptoms associated with venous disorders, such as pain, heaviness, and leg cramps. Its anti-inflammatory properties contribute to its therapeutic effects.
Pharmacokinetics
Dobesylate is absorbed relatively quickly after oral administration, with peak plasma concentrations occurring within a few hours. It undergoes hepatic metabolism, and its elimination half-life is variable among individuals, primarily excreted through urine. The drug is generally well-tolerated with a low incidence of side effects.
Adverse effects
- Nausea
- Diarrhea
- Abdominal pain
- Headache
- Dizziness
- Allergic reactions
Precautions
- Use with caution in patients with renal impairment
- Monitor for gastrointestinal bleeding in patients with a history of peptic ulcer disease
Pregnancy
There is limited data on the use of dobesylate in pregnancy. It should be used only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether dobesylate is excreted in human milk. Caution should be exercised when administering to breastfeeding women.
Storage
Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.
Formulations
- Tablets
- Capsules
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.