LYSER FORTE TABLETS
SERRATIOPPEPTIDASE TABLETS
What it does
Serratiopeptidase is an enzyme that helps reduce inflammation and pain.
Commonly used for: inflammation, pain relief, swelling
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:11:38 · updated 2026-07-20 08:54:47
About this medicine
Serratiopeptidase is an enzyme that helps reduce inflammation and pain.
What it treats
- inflammation
- pain relief
- swelling
How it works
It breaks down proteins involved in inflammation, which helps reduce swelling and pain.
Who it's for
It is used by people who have conditions that cause inflammation or pain.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: serratioppeptidase
Serratiopeptidase, also known as serrapeptase, is a proteolytic enzyme derived from the silkworm. It is primarily used for its anti-inflammatory and analgesic properties. Serratiopeptidase has been studied for its potential to reduce pain and swelling in various conditions, including arthritis and post-operative inflammation. It is thought to aid in the breakdown of fibrin, a protein involved in blood clotting and wound healing, which may contribute to its therapeutic effects.
Indications
- Post-operative pain
- Trauma-related inflammation
- Chronic pain syndromes
- Osteoarthritis
- Sinusitis
Dosage
Children: Refer to specific product guidelines and prescribing information as doses may vary based on preparation and condition being treated.
Adults: Refer to specific product guidelines and prescribing information as doses may vary based on preparation and condition being treated.
Mechanism of action
Serratiopeptidase exerts its effects through the cleavage of peptide bonds in proteins, thereby promoting the degradation of inflammatory mediators and promoting the resolution of inflammation. It is believed to inhibit the release of substances that promote pain and swelling, thus facilitating tissue healing and reducing the formation of scar tissue.
Pharmacodynamics
The pharmacodynamics of serratiopeptidase involve its ability to modulate inflammatory processes and enhance tissue repair. It has been shown to decrease swelling and improve circulation, which may be beneficial in reducing pain and inflammation associated with various medical conditions. The enzyme's proteolytic activity also aids in the breakdown of necrotic tissue, potentially facilitating recovery from injury or surgery.
Pharmacokinetics
Serratiopeptidase is typically administered orally and is absorbed within the gastrointestinal tract. The enzyme exhibits relatively rapid absorption, though the exact pharmacokinetic parameters, such as peak plasma concentration and elimination half-life, are not well characterized. Its activity can be influenced by the presence of food, and it is generally recommended to take the enzyme on an empty stomach to maximize its bioavailability. The metabolic pathways and the extent to which serratiopeptidase is metabolized in the liver or eliminated via the kidneys remain to be fully elucidated.
Adverse effects
- Gastrointestinal discomfort
- Nausea
- Diarrhea
- Allergic reactions
Precautions
- Use with caution in patients with bleeding disorders
- Caution in patients undergoing surgery or taking anticoagulants
Pregnancy
There is insufficient evidence regarding the safety of serrapeptase during pregnancy. It is advisable to avoid use unless deemed necessary by a healthcare provider.
Breast-feeding
There is limited data on serrapeptase excretion in breast milk. Caution is recommended if used during lactation.
Storage
Store in a cool, dry place away from direct sunlight.
Formulations
- Tablets
- Capsules
- Enteric-coated formulations
- Powder for oral solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.