CINOD 10
Cilnidipine 10 mg
What it does
Cilnidipine is a medication used to help lower high blood pressure.
Commonly used for: high blood pressure (hypertension)
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Rwanda Food and Drugs Authority · fetched 2026-03-11 22:07:16 · updated 2026-09-17 02:30:43
About this medicine
Cilnidipine is a medication used to help lower high blood pressure.
What it treats
- high blood pressure (hypertension)
How it works
Cilnidipine works by relaxing the blood vessels, which helps to reduce the pressure of blood flowing through them.
Who it's for
This medication is for adults who need help controlling their high blood pressure.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: cilnidipine
BNF-referencedCilnidipine is a calcium channel blocker primarily used for the treatment of hypertension. It exhibits a dual mechanism of action by blocking both L-type and N-type calcium channels, leading to vasodilation and reduced sympathetic nervous system output. This results in effective blood pressure control with a lower risk of reflex tachycardia compared to some other antihypertensives.
Indications
- Hypertension
- Essential hypertension
Dosage
Children: Refer to BNF for Children for specific dosing guidance.
Adults: Refer to BNF for specific dosing guidance.
Mechanism of action
Cilnidipine acts on the L-type calcium channels of blood vessels by blocking the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. It also works on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of norepinephrine and suppressing the increase in stress blood pressure.
Pharmacodynamics
Administration of cilnidipine has been shown to present an antisympathetic profile in vitro and in vivo. It decreases blood pressure safely and effectively without excessive blood pressure reduction or tachycardia.
Contra-indications
- Hypersensitivity to cilnidipine or any of its components
- Severe hypotension
- Aortic stenosis
- Cardiogenic shock
Adverse effects
- Headache
- Dizziness
- Flushing
- Peripheral edema
- Palpitations
- Constipation
- Nausea
Interactions
- May enhance the effect of other antihypertensive agents
- Caution when used with calcium channel blockers
- May interact with drugs that affect cytochrome P450 enzymes
Precautions
- Use with caution in patients with hepatic or renal impairment
- Monitor blood pressure regularly during therapy
- Caution in elderly patients and those with a history of heart failure
Pregnancy
Cilnidipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult relevant guidelines.
Breast-feeding
It is not known whether cilnidipine is excreted in human milk. Caution should be exercised when administering to a nursing mother.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Tablets: 10 mg, 20 mg
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: cilnidipine
PubChem CID 5282138Molecular formula: C27H28N2O7
Mechanism of action
Cilnidipine acts on the L-type calcium channels of blood vessels by blocking the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. Cilnidipine also works on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of norepinephrine and suppressing the increase in stress blood pressure.
Pharmacodynamics
Administration of cilnidipine has been shown to present an antisympathetic profile in vitro and in vivo. It decreases blood pressure safely and effectively without excessive blood pressure reduction or tachycardia.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.
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