NOVILEC-20

Indications

• Hypertension
• Essential hypertension

Dosage

Children: Refer to BNF for Children for specific dosing guidance.

Adults: Refer to BNF for specific dosing guidance.

Mechanism of action

Cilnidipine acts on the L-type calcium channels of blood vessels by blocking the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. It also works on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of norepinephrine and suppressing the increase in stress blood pressure.

Pharmacodynamics

Administration of cilnidipine has been shown to present an antisympathetic profile in vitro and in vivo. It decreases blood pressure safely and effectively without excessive blood pressure reduction or tachycardia.

Contra-indications

• Hypersensitivity to cilnidipine or any of its components
• Severe hypotension
• Aortic stenosis
• Cardiogenic shock

Adverse effects

• Headache
• Dizziness
• Flushing
• Peripheral edema
• Palpitations
• Constipation
• Nausea

Interactions

• May enhance the effect of other antihypertensive agents
• Caution when used with calcium channel blockers
• May interact with drugs that affect cytochrome P450 enzymes

Precautions

• Use with caution in patients with hepatic or renal impairment
• Monitor blood pressure regularly during therapy
• Caution in elderly patients and those with a history of heart failure

Pregnancy

Cilnidipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult relevant guidelines.

Breast-feeding

It is not known whether cilnidipine is excreted in human milk. Caution should be exercised when administering to a nursing mother.

Storage

Store at room temperature, away from moisture and heat. Keep out of reach of children.

Formulations

• Tablets: 10 mg, 20 mg

Mechanism of action

Cilnidipine acts on the L-type calcium channels of blood vessels by blocking the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. Cilnidipine also works on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of norepinephrine and suppressing the increase in stress blood pressure.

Pharmacodynamics

Administration of cilnidipine has been shown to present an antisympathetic profile in vitro and in vivo. It decreases blood pressure safely and effectively without excessive blood pressure reduction or tachycardia.