CIPROBAY HC OTIC DROPS
CIPROFLOXACINHYDROCORTISONE
What it does
Ciprofloxacin and hydrocortisone is a combination medicine used to treat infections and reduce inflammation.
Commonly used for: ear infections, skin infections, inflammation in the ears or skin
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
Ask about this medicine
Answers come only from this medicine's registration record, BNF monograph and interaction data - not medical advice.
Hard to find? We help patients in Kenya source rare medicines. We don't sell or dispense medicines - licensed pharmacies do.
Source this medicineRegistration & product details
Source: Pharmacy and Poisons Board · fetched 2026-01-28 22:00:37 · updated 2026-03-23 04:45:45
About this medicine
Ciprofloxacin and hydrocortisone is a combination medicine used to treat infections and reduce inflammation.
What it treats
- ear infections
- skin infections
- inflammation in the ears or skin
How it works
Ciprofloxacin is an antibiotic that fights bacteria, while hydrocortisone is a steroid that helps reduce swelling and irritation.
Who it's for
This medicine is suitable for adults and children with certain types of infections and inflammation.
Cautions
- • Do not use if you are allergic to ciprofloxacin or hydrocortisone.
- • Consult your doctor if you have other health conditions or are taking other medications.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: ciprofloxacinhydrocortisone
Ciprofloxacin and hydrocortisone is a combination medication that leverages the antibacterial properties of ciprofloxacin, a fluoroquinolone antibiotic, and the anti-inflammatory effects of hydrocortisone, a corticosteroid. This combination is primarily used in the treatment of infections where inflammation is also a concern, particularly in otic formulations for ear infections and conditions such as otitis externa. The synergistic effect helps to mitigate inflammation while effectively treating bacterial infections.
Indications
- Otitis externa
- Bacterial ear infections
- Inflammatory conditions associated with bacterial infections
Dosage
Children: Refer to the BNF for Children for appropriate dosing based on the child's age and weight.
Adults: Refer to the BNF for specific dosing recommendations based on the condition being treated.
Mechanism of action
Ciprofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication, transcription, and repair. This leads to the inhibition of bacterial cell growth and division. Hydrocortisone exerts its effects by binding to glucocorticoid receptors, leading to the modulation of inflammatory responses by inhibiting the release of inflammatory mediators and promoting anti-inflammatory pathways.
Pharmacodynamics
The antibacterial activity of ciprofloxacin is concentration-dependent, meaning that its efficacy increases with higher concentrations relative to the minimum inhibitory concentration (MIC) for the target bacteria. Hydrocortisone reduces inflammation and immune response by decreasing the migration of leukocytes to sites of inflammation and interfering with the function of inflammatory mediators. This combination allows for a reduction in symptoms associated with inflammation alongside effective bacterial eradication.
Pharmacokinetics
Ciprofloxacin is absorbed well following oral administration, with peak plasma concentrations occurring within 1 to 2 hours. It has a bioavailability of about 70%. Ciprofloxacin is widely distributed throughout body tissues and fluids, including the lungs, liver, and kidneys. It is primarily excreted unchanged in the urine. Hydrocortisone also has good bioavailability and is metabolized in the liver, with renal excretion of its metabolites. The half-life of hydrocortisone is approximately 1 to 2 hours, with effects lasting longer due to its anti-inflammatory action.
Contra-indications
- Hypersensitivity to ciprofloxacin, hydrocortisone, or any of the excipients
- Viral infections of the ear canal
- Fungal infections of the ear canal
Adverse effects
- Local irritation
- Burning sensation
- Itching
- Dryness of the ear
- Systemic effects may occur with prolonged use
Precautions
- Use with caution in patients with a history of hypersensitivity reactions
- Should not be used in patients with perforated tympanic membrane
Pregnancy
Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Hydrocortisone is considered safe during pregnancy but should be used judiciously.
Breast-feeding
Ciprofloxacin is excreted in breast milk; caution should be exercised when administering to breastfeeding mothers. Hydrocortisone is also excreted in breast milk but is generally considered safe at therapeutic doses.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Otic solution containing ciprofloxacin 0.3% and hydrocortisone 1%
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.