DHEA-SR
SUSTAINED RELEASE DEHYROEPIANDOSTERONE ACETATE
What it does
Dehydroepiandrosterone (DHEA) is a hormone that helps to balance other hormones in the body and is often used to support overall well-being.
Commonly used for: adrenal insufficiency, hormonal imbalance, age-related health issues
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
Ask about this medicine
Answers come only from this medicine's registration record, BNF monograph and interaction data - not medical advice.
Hard to find? We help patients in Kenya source rare medicines. We don't sell or dispense medicines - licensed pharmacies do.
Source this medicineRegistration & product details
Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:27:43 · updated 2026-07-26 09:26:54
About this medicine
Dehydroepiandrosterone (DHEA) is a hormone that helps to balance other hormones in the body and is often used to support overall well-being.
What it treats
- adrenal insufficiency
- hormonal imbalance
- age-related health issues
How it works
DHEA is produced by the adrenal glands and helps to produce other hormones, playing a role in regulating bodily functions.
Who it's for
Adults seeking to manage hormonal levels or improve their health as they age.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: dehyroepiandosterone
Dehydroepiandrosterone (DHEA) is a naturally occurring steroid hormone produced primarily in the adrenal glands, with smaller amounts synthesized in the gonads and brain. It serves as a precursor to both androgens and estrogens, thus playing a crucial role in the biosynthesis of sex hormones. DHEA levels peak in early adulthood and gradually decline with age, which has led to interest in its potential effects on aging, mood, and overall health.
Indications
- Adrenal insufficiency
- Chronic fatigue syndrome
- Depression
- Osteoporosis
- Menopausal symptoms
- Age-related cognitive decline
Dosage
Children: The safety and efficacy of DHEA in pediatric populations have not been well established. Dosing in children should be approached with caution and under strict medical supervision.
Adults: Dosing of DHEA varies based on the indication and should be determined by a healthcare professional. Typical doses range from 25 to 200 mg daily, but specific dosing should be individualized.
Mechanism of action
DHEA exerts its effects primarily through the conversion to other hormones, such as testosterone and estrogen. It acts on androgen and estrogen receptors, influencing various physiological processes such as immune response, bone density, and muscle strength. DHEA may also have neuroprotective effects, possibly through the modulation of neurosteroid levels in the brain.
Pharmacodynamics
As a precursor to sex hormones, DHEA influences the development and maintenance of male and female secondary sexual characteristics. It has been studied for its potential benefits in improving mood, energy levels, and cognitive function. DHEA also plays a role in modulating the immune system and has been investigated for its potential effects on body composition and metabolism.
Pharmacokinetics
DHEA is rapidly absorbed after oral administration, with peak plasma concentrations typically occurring within 1 to 2 hours. It has a half-life of approximately 15 to 30 minutes, and is extensively metabolized in the liver, primarily to androstenedione, testosterone, and estrone. Its bioavailability can be affected by factors such as age, sex, and the presence of certain medical conditions. The elimination of DHEA and its metabolites occurs primarily via urine.
Contra-indications
- Hypersensitivity to dehydroepiandrosterone or any of its components
- Pregnancy
- Breastfeeding
- Hormone-sensitive cancers
Adverse effects
- Acne
- Hair loss
- Mood changes
- Headache
- Hypertension
- Insomnia
- Gastrointestinal disturbances
Interactions
- Anticoagulants
- Antidiabetic medications
- Hormonal therapies
- Corticosteroids
- Certain antidepressants
Precautions
- Use in individuals with a history of hormone-sensitive conditions
- Monitor for signs of adrenal suppression
- Assess cardiovascular health before use
Pregnancy
Not recommended due to potential hormonal effects on fetal development.
Breast-feeding
Not recommended as safety during lactation has not been established.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Oral tablets
- Capsules
- Topical creams
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.