Ditrox

Indications

• Gastrointestinal nematode infections
• Cestode infections
• Liver fluke infections

Dosage

Children: Refer to the BNF for Children for specific dosage guidelines in paediatric patients.

Adults: Refer to the BNF for specific dosage recommendations based on the condition being treated.

Mechanism of action

Nitroxinil acts by inhibiting energy metabolism in helminths, affecting their ability to maintain homeostasis. It interferes with the parasite's mitochondrial function, leading to depletion of ATP and eventual death of the parasite. This mechanism primarily targets the parasites' energy production pathways.

Pharmacodynamics

Nitroxinil exhibits selective toxicity towards helminths due to differences in mitochondrial biochemistry between the parasites and host cells. Its action leads to paralysis and death of the parasites, facilitating their expulsion from the host organism.

Pharmacokinetics

Nitroxinil is absorbed in the gastrointestinal tract following oral administration, with peak plasma concentrations occurring within a few hours. It is metabolized in the liver, and its metabolites are primarily excreted through the urine and feces. The drug has a relatively short half-life, necessitating multiple doses for sustained therapeutic effect.

Pregnancy

There is limited data on the use of nitroxinil during pregnancy. Caution is advised, and it should only be used if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

It is not known whether nitroxinil is excreted in human milk. Caution is recommended when administering to nursing mothers.

Storage

Store in a cool, dry place away from light. Keep out of reach of children.