DOLO-DENK 100 MG/ G GEL

Indications

• Localized musculoskeletal pain
• Arthritis
• Tendonitis
• Bursitis
• Sports injuries

Dosage

Children: Refer to the BNF for Children for appropriate dosing information.

Adults: Refer to the BNF for specific dosing guidelines.

Mechanism of action

Etofenamate acts as a non-selective cyclooxygenase (COX) inhibitor, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation and pain. This inhibition leads to decreased inflammation and provides analgesic effects.

Pharmacodynamics

Etofenamate exhibits anti-inflammatory, analgesic, and antipyretic properties typical of NSAIDs. By inhibiting the COX enzymes, it effectively reduces the production of prostaglandins responsible for the pain and swelling associated with inflammatory conditions.

Pharmacokinetics

The pharmacokinetics of etofenamate, particularly in topical formulations, indicates that it is absorbed through the skin. The systemic absorption is relatively low, which contributes to a reduced risk of systemic side effects. The onset of action is typically rapid at the site of application, with peak effects occurring within a few hours.

Pregnancy

Etofenamate should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid use, particularly in the third trimester, due to the risk of premature closure of the ductus arteriosus.

Breast-feeding

Caution is advised when using etofenamate during breastfeeding. It is not known if etofenamate is excreted in human milk.

Storage

Store below 25 degrees Celsius in a tightly closed container. Protect from light.

Mechanism of action

Etofenamate is a topical NSAID that reduces inflammation and pain by inhibiting the cyclooxygenase (COX) pathway and reducing prostaglandin synthesis (non-selective COX inhibition reported).