DOLO-DENK GEL
ETOFENAMATE
What it does
Etofenamate is a topical medication used to relieve pain and inflammation.
Commonly used for: muscle pain, joint pain, arthritis
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:38:37 · updated 2026-07-20 11:12:52
About this medicine
Etofenamate is a topical medication used to relieve pain and inflammation.
What it treats
- muscle pain
- joint pain
- arthritis
How it works
Etofenamate works by reducing inflammation and blocking pain signals in the affected area.
Who it's for
It is suitable for adults and children over a certain age, as advised by a healthcare provider.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: etofenamate
BNF-referencedEtofenamate is a non-steroidal anti-inflammatory drug (NSAID) that is primarily used topically to alleviate pain and inflammation. It is particularly effective in treating musculoskeletal disorders and localized inflammatory conditions. Its formulation allows for localized application, minimizing systemic exposure and potential side effects associated with oral NSAIDs.
Indications
- Localized musculoskeletal pain
- Arthritis
- Tendonitis
- Bursitis
- Sports injuries
Dosage
Children: Refer to the BNF for Children for appropriate dosing information.
Adults: Refer to the BNF for specific dosing guidelines.
Mechanism of action
Etofenamate acts as a non-selective cyclooxygenase (COX) inhibitor, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation and pain. This inhibition leads to decreased inflammation and provides analgesic effects.
Pharmacodynamics
Etofenamate exhibits anti-inflammatory, analgesic, and antipyretic properties typical of NSAIDs. By inhibiting the COX enzymes, it effectively reduces the production of prostaglandins responsible for the pain and swelling associated with inflammatory conditions.
Pharmacokinetics
The pharmacokinetics of etofenamate, particularly in topical formulations, indicates that it is absorbed through the skin. The systemic absorption is relatively low, which contributes to a reduced risk of systemic side effects. The onset of action is typically rapid at the site of application, with peak effects occurring within a few hours.
Pregnancy
Etofenamate should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid use, particularly in the third trimester, due to the risk of premature closure of the ductus arteriosus.
Breast-feeding
Caution is advised when using etofenamate during breastfeeding. It is not known if etofenamate is excreted in human milk.
Storage
Store below 25 degrees Celsius in a tightly closed container. Protect from light.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: etofenamate
PubChem CID 35375Molecular formula: C18H18F3NO4
Mechanism of action
Etofenamate is a topical NSAID that reduces inflammation and pain by inhibiting the cyclooxygenase (COX) pathway and reducing prostaglandin synthesis (non-selective COX inhibition reported).
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.