FEDATE SYRUP
SODIUM FEREDETATE BP
What it does
Feredetate is a medication used to treat iron deficiency or low iron levels in the body.
Commonly used for: iron deficiency, low iron levels (ferropenia)
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:47:45 · updated 2026-07-26 11:38:13
About this medicine
Feredetate is a medication used to treat iron deficiency or low iron levels in the body.
What it treats
- iron deficiency
- low iron levels (ferropenia)
How it works
Feredetate helps to increase the amount of iron in your body, which is important for making red blood cells and keeping your energy levels up.
Who it's for
This medication is for individuals who have low iron levels, often due to poor diet, certain health conditions, or blood loss.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: feredetate
Feredetate is an iron chelator used primarily in the treatment of iron overload conditions, such as hemochromatosis and secondary iron overload due to repeated blood transfusions. It functions by binding to excess iron in the body, facilitating its excretion and reducing the risk of iron-related organ damage.
Indications
- Iron overload due to hereditary hemochromatosis
- Secondary iron overload from repeated blood transfusions
- Chronic iron overload resulting from ineffective erythropoiesis
Dosage
Children: Refer to the BNF for Children for appropriate paediatric dosing information.
Adults: Refer to the relevant clinical guidelines and BNF for specific dosing information.
Mechanism of action
Feredetate works by forming stable complexes with ferric ions, thereby reducing free iron levels in the plasma. This process enhances the elimination of excess iron via the kidneys and promotes its safe excretion from the body. The chelation of iron prevents the formation of harmful free radicals, contributing to its protective effects against oxidative stress.
Pharmacodynamics
The pharmacodynamics of feredetate involve its ability to bind iron ions tightly, which decreases the bioavailability of free iron. This action is crucial for preventing iron-induced tissue damage and related complications. The drug's effectiveness is also influenced by the concentration of iron in the body and the presence of other chelating agents.
Pharmacokinetics
Feredetate is administered parenterally, allowing for rapid absorption into the bloodstream. Once in circulation, it distributes to various tissues, but primarily targets areas with iron overload. The elimination half-life is variable, depending on the degree of iron saturation and renal function. Excretion occurs mainly via the kidneys, with a smaller proportion eliminated through the feces.
Contra-indications
- Hypersensitivity to the active substance or any of the excipients
- Severe renal impairment
- Hemochromatosis
- Hemosiderosis
- Active infections
Adverse effects
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Allergic reactions (rash, itching)
- Iron overload
- Headache
- Dizziness
- Hypotension
- Injection site reactions
Interactions
- Antacids may decrease absorption and efficacy of feredetate
- Tetracyclines may form insoluble complexes with iron, reducing their efficacy
- Certain medications that affect iron metabolism or absorption
Precautions
- Monitor iron levels during therapy to avoid iron overload
- Caution in patients with a history of gastrointestinal disorders
- Use with care in patients with liver disease
- Assess for potential drug interactions
Pregnancy
Feredetate should only be used during pregnancy if the benefits outweigh the risks. Consult relevant guidelines.
Breast-feeding
Feredetate is excreted in breast milk. Caution is advised when administering to nursing mothers.
Storage
Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.
Formulations
- Injectable solution
- Oral tablets
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.