FIBEREX 3.75MG GRANULES

Indications

• Constipation
• Irritable bowel syndrome (IBS)
• Diverticular disease
• Cholesterol management
• Blood sugar control in diabetes

Dosage

Children: For children, it is recommended to consult a healthcare provider for appropriate dosing based on age and weight, as specific pediatric dosing

Adults: For adults, the typical dosage is 1 to 2 teaspoons (5 to 10 grams) of psyllium husk taken 1 to 3 times daily, mixed with at least 8 ounces of water or other liquid.

Mechanism of action

Psyllium husk acts as a bulk-forming laxative. It is not digested by the body, but when mixed with water, it expands and forms a viscous gel. This gel increases the bulk of the stool and triggers peristalsis, enhancing bowel movements. Additionally, it may slow down the absorption of carbohydrates and fats, contributing to its cholesterol-lowering and blood sugar-regulating effects.

Pharmacodynamics

The primary pharmacodynamic effect of husk is its ability to increase stool bulk and water content, which facilitates easier passage of stool through the intestines. This leads to improved bowel regularity and relief from constipation. Furthermore, psyllium husk has been shown to have a mild effect on lowering serum cholesterol levels, particularly low-density lipoprotein (LDL) cholesterol, and may improve glycemic control in patients with type 2 diabetes.

Pharmacokinetics

Psyllium husk is not absorbed systemically; it remains in the gastrointestinal tract, where it exerts its effects. The onset of action for bowel regulation typically occurs within 12 to 72 hours after ingestion, depending on the individual's digestive transit time and fluid intake. Adequate hydration is essential to maximize its efficacy and prevent potential gastrointestinal obstruction.

Adverse effects

• Bloating
• Abdominal cramping
• Diarrhea
• Nausea

Precautions

• Ensure adequate fluid intake when using husk to prevent gastrointestinal obstruction
• Monitor for allergic reactions in sensitive individuals

Pregnancy

Generally considered safe to use during pregnancy, but always consult a healthcare provider.

Breast-feeding

Considered safe while breastfeeding, but consult a healthcare provider for personalized advice.

Storage

Store in a cool, dry place, away from direct sunlight and moisture.

Formulations

• Psyllium husk powder
• Psyllium husk capsules
• Psyllium husk granules

Indications

• Constipation
• Irritable bowel syndrome
• Diverticular disease
• Hyperlipidemia

Dosage

Children: Refer to the BNF for Children for appropriate dosing guidelines in children.

Adults: Refer to the BNF for specific dosing recommendations, typically starting with a standard dose that can be adjusted based on individual response.

Mechanism of action

Ispaghula acts as a soluble fiber that increases the water content and bulk of the stool. This action stimulates peristalsis (the wave-like muscle contractions of the intestines) and facilitates easier passage of stool through the gastrointestinal tract. It may also contribute to the modulation of intestinal microbiota and has prebiotic effects, promoting the growth of beneficial gut bacteria.

Pharmacodynamics

Ispaghula exhibits its pharmacodynamic effects through its ability to absorb water and swell in the gastrointestinal tract, which increases stool mass and triggers bowel movements. This bulk-forming property helps alleviate constipation and maintains bowel health. Additionally, the gel-like substance formed can slow down the absorption of glucose and cholesterol, providing further metabolic benefits.

Pharmacokinetics

Ispaghula is not absorbed in the gastrointestinal tract, which means it does not have systemic effects. It passes through the digestive system and is excreted unchanged. The onset of action typically occurs within 12 to 72 hours after ingestion, depending on the individual and the volume of fluid consumed with the fiber. Adequate hydration is necessary for optimal efficacy.

Contra-indications

• Intestinal obstruction
• Severe dehydration
• Dysphagia

Adverse effects

• Abdominal bloating
• Flatulence
• Diarrhea
• Constipation
• Esophageal obstruction

Interactions

• May reduce the absorption of concomitantly administered oral medications due to its bulk-forming properties
• Caution should be exercised when taken with anticoagulants as it may affect their absorption

Precautions

• Adequate fluid intake should be ensured to prevent esophageal obstruction
• Caution in patients with a history of gastrointestinal disorders

Pregnancy

Generally considered safe for use during pregnancy, but it is advisable to consult a healthcare provider.

Breast-feeding

Considered safe during breastfeeding; however, maternal hydration should be maintained.

Storage

Store in a cool, dry place, away from direct sunlight.

Formulations

• Powder for oral suspension
• Granules for oral intake
• Tablets