GELOFUSINE 40MG/ML SOLUTION FOR INFUSION

Indications

• Low blood volume
• Hypovolemic shock
• Burns
• Cardiopulmonary bypass

Dosage

Children: Initially 10-20 mL per kilogram. Adjust according to the patient's condition and response, using 3.5-4% solution. Use under specialist supervision to mitigate the risk of fluid overload.

Adults: Dose according to requirements, typically administered intravenously. Consult product literature for specific dosing guidance.

Mechanism of action

Gelatin acts as a plasma expander by increasing the oncotic pressure in the vascular compartment, which helps to retain fluid within the bloodstream and restore circulating blood volume. This mechanism aids in maintaining blood pressure and improving tissue perfusion.

Pharmacodynamics

Gelatin solutions increase blood volume and improve hemodynamic stability in patients experiencing hypovolemic conditions. By drawing water into the vascular space, they help to counteract the effects of low blood volume, such as hypotension and compromised organ perfusion.

Pharmacokinetics

Gelatin is administered intravenously, and its effects can be observed relatively quickly. The half-life and the metabolic clearance depend on the formulation and concentration of the solution. Gelatin is gradually metabolized by macrophages and eliminated by the renal system. Close monitoring of fluid balance is essential, particularly in patients with cardiac or renal impairment.

Contra-indications

• Severe liver disease
• History of circulatory disease
• Severe cardiac disease

Adverse effects

• Fever
• Flushing
• Nausea
• Urticaria
• Rare or very rare shock

Interactions

• Calcium salts

Precautions

• Monitor cardiovascular and respiratory function
• Correct dehydration when administering
• Administer slowly to avoid rapid rise in blood pressure and cardiac failure
• Increased capillary permeability

Pregnancy

Consult product literature for specific guidance regarding use in pregnancy.

Breast-feeding

Consult product literature for specific guidance regarding use in breastfeeding.

Storage

Store at controlled room temperature, protect from light. Refer to product-specific storage instructions.

Formulations

• 5% solution for infusion
• 20% solution for infusion
• Concentrated solution (15-25% protein)
• Isotonic solution (3.5-5% protein)

Indications

• Hypovolemia
• Hemorrhagic shock
• Fluid resuscitation during surgery
• Trauma management

Dosage

Children: Refer to specific clinical guidelines or product information for dosing recommendations.

Adults: Refer to specific clinical guidelines or product information for dosing recommendations.

Mechanism of action

Succinylated gelatins work by increasing oncotic pressure within the blood vessels, which helps to draw fluid from surrounding tissues into the vascular space. This action increases blood volume and improves circulation. The succinylation process reduces the antigenicity of gelatin, which minimizes the risk of allergic reactions.

Pharmacodynamics

The pharmacodynamic effects of succinylated gelatins include rapid expansion of circulating blood volume, which can improve hemodynamic stability in patients experiencing hypovolemic shock. The increase in plasma volume leads to improved cardiac output and tissue perfusion, facilitating recovery from blood loss.

Pharmacokinetics

Succinylated gelatins are typically administered intravenously. They are rapidly distributed in the vascular compartment and exert their effects almost immediately. The metabolism of these products occurs in the liver, where they are broken down into smaller peptides and amino acids. The elimination of succinylated gelatins from the body is primarily through renal excretion. Because they are large molecules, they are not easily filtered by the kidneys, which allows for prolonged action within the circulatory system.

Pregnancy

There is limited information on the use of succinylated in pregnancy. It is essential to assess the risk versus benefit before administration.

Breast-feeding

Caution is advised when administering succinylated during breastfeeding, as its effects on nursing infants are not well-studied.

Storage

Store at room temperature, away from moisture and heat. Protect from light and keep out of reach of children.