AJOXIL 200MG TABLETS

Indications

• Motion sickness
• Nausea and vomiting
• Peptic ulcers
• Excessive salivation
• Preoperative sedation

Dosage

Children: Refer to established dosing guidelines as specific doses are not provided.

Adults: Refer to established dosing guidelines as specific doses are not provided.

Mechanism of action

Ehxine works by antagonizing the effects of acetylcholine at muscarinic receptors, which results in decreased secretions and smooth muscle relaxation. This action is particularly beneficial in reducing salivation, bronchial secretions, and gastrointestinal motility. It may also have a central effect, reducing vestibular stimulation which helps in motion sickness management.

Pharmacodynamics

The pharmacodynamic profile of ehxine includes its ability to cause muscle relaxation, reduce secretions, and provide antinausea effects. The onset of action can vary based on the route of administration, with intravenous administration yielding faster effects compared to oral formulations. The duration of action is generally several hours, depending on the dose and individual metabolic factors.

Pharmacokinetics

Ehxine is absorbed well from the gastrointestinal tract when taken orally, with peak plasma concentrations typically occurring within 1 to 2 hours. It is metabolized primarily in the liver and excreted in urine. The half-life can vary, but it is generally around 3 to 5 hours, with a notable volume of distribution suggesting extensive tissue binding. Factors such as age, liver function, and concurrent medications can influence its pharmacokinetics.

Contra-indications

• Hypersensitivity to ehxine or any component of the formulation
• Severe hepatic impairment
• Pregnancy (unless the potential benefit justifies the potential risk to the fetus)

Adverse effects

• Nausea
• Vomiting
• Dizziness
• Headache
• Hypotension
• Bradycardia
• Rash
• Fatigue

Interactions

• May interact with anticoagulants, increasing the risk of bleeding
• Concomitant use with other antihypertensives may potentiate hypotensive effects
• Caution advised when used with drugs that affect hepatic metabolism

Precautions

• Monitor blood pressure regularly during treatment
• Use with caution in patients with a history of cardiovascular disease
• Assess renal function before and during therapy
• Consider potential interactions with other medications

Pregnancy

The safety of ehxine during pregnancy has not been established. It should only be used if the potential benefit justifies the risk.

Breast-feeding

It is not known whether ehxine is excreted in human milk. Caution should be exercised when administering to nursing mothers.

Storage

Store at room temperature, away from moisture and heat. Keep out of reach of children.

Formulations

• Tablets
• Injectable solution