FENOR INJECTION ( Florfenicol 20%)

Indications

• Bacterial infections in livestock
• Respiratory disease in cattle
• Foot rot in sheep
• Skin infections in dogs and cats
• Treatment of salmonellosis

Dosage

Children: Refer to the BNF for Children for appropriate dosing information in pediatric cases.

Adults: Refer to the BNF for specific dosing guidelines based on the condition being treated and the animal species.

Mechanism of action

Florfenicol exerts its antibacterial effects by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit, preventing the formation of peptide bonds during translation, which ultimately halts the growth of susceptible bacteria.

Pharmacodynamics

Florfenicol demonstrates bacteriostatic activity, meaning it inhibits the growth and replication of bacteria rather than directly killing them. The drug's efficacy is influenced by factors such as concentration and duration of exposure, with higher concentrations leading to greater antibacterial activity. It is effective against a wide range of pathogens, including strains resistant to other antibiotics.

Pharmacokinetics

Florfenicol is absorbed well after parenteral administration and has good tissue distribution. It is primarily metabolized in the liver and excreted through the urine. The half-life varies depending on the route of administration and species, but it generally ranges from 4 to 8 hours in most animals.

Adverse effects

• Diarrhoea
• Anorexia
• Vomiting
• Injection site reaction
• Allergic reactions

Precautions

• Use with caution in animals with liver or kidney impairment
• Monitor for signs of hypersensitivity

Pregnancy

Safety in pregnancy has not been established. Use only if the benefits outweigh the risks.

Breast-feeding

Not established whether florfenicol is excreted in milk. Exercise caution when administering to nursing animals.

Storage

Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.

Formulations

• Injectable solution
• Oral suspension