WELLMAN 50 PLUS TABLETS

Indications

• Antioxidant support
• Detoxification
• Support in conditions related to oxidative stress
• Potential adjunct in liver diseases
• Immune system support

Dosage

Children: Refer to clinical guidelines for specific dosing based on indication and formulation.

Adults: Refer to clinical guidelines for specific dosing based on indication and formulation.

Mechanism of action

L-glutathione exerts its effects primarily as an antioxidant by neutralizing reactive oxygen species (ROS) and free radicals, thereby preventing oxidative damage to cellular components such as lipids, proteins, and DNA. It also participates in the detoxification of harmful substances through conjugation reactions and plays a role in the regeneration of other antioxidants, such as vitamins C and E. Furthermore, glutathione is involved in various enzymatic reactions and is crucial for the proper functioning of the immune system.

Pharmacodynamics

L-glutathione aids in maintaining the redox state of cells, ensuring that the balance between oxidants and antioxidants is preserved. It influences various signaling pathways related to inflammation, apoptosis, and cellular proliferation. Elevated levels of glutathione are associated with enhanced cellular resilience against stressors, while depletion can lead to increased susceptibility to oxidative damage and various diseases.

Pharmacokinetics

L-glutathione is absorbed through the gastrointestinal tract, although its bioavailability can be limited due to its degradation by gastrointestinal enzymes. It is transported into cells via specific transport systems, where it is synthesized from its constituent amino acids. The metabolism of glutathione involves its conversion to cysteine, which can then be used for protein synthesis or further metabolized. The elimination of glutathione and its metabolites occurs primarily through the kidneys, with urinary excretion being the main pathway for its clearance.

Adverse effects

• Gastrointestinal disturbances
• Nausea
• Abdominal cramps
• Diarrhea
• Allergic reactions

Precautions

• Use with caution in patients with asthma or allergic conditions
• Consider potential interactions with other antioxidant supplements

Pregnancy

Safety during pregnancy has not been established; use only if clearly needed.

Breast-feeding

It is not known whether L-glutathione is excreted in human milk; caution is advised.

Storage

Store in a cool, dry place away from direct sunlight, and keep out of reach of children.

Formulations

• Oral capsules
• Oral tablets
• Injectable solution

Indications

• Potential role in bone health
• Support for connective tissue formation
• May aid in mineral metabolism

Dosage

Children: There is no established clinical dosage for silicon in paediatric populations, as it is not classified as an essential nutrient.

Adults: There is no established clinical dosage for silicon in adults, as it is not classified as an essential nutrient.

Mechanism of action

Silicon is believed to enhance the synthesis of glycosaminoglycans and collagen, which are important for the structural integrity of connective tissues. It may also influence the activity of certain enzymes involved in bone mineralization, thus playing a role in maintaining bone density and health.

Pharmacodynamics

The pharmacodynamics of silicon is not fully elucidated; however, it is thought to involve the modulation of bone metabolism and the promotion of connective tissue health. Silicon may have a synergistic effect with other minerals, such as calcium and magnesium, aiding in their utilization and metabolism in the body.

Pharmacokinetics

The pharmacokinetics of silicon is complex, as it is not absorbed through typical gastrointestinal pathways. Instead, silicon is thought to be taken up in the form of silicates and then distributed throughout the body, particularly in connective tissues. The elimination of silicon occurs primarily through renal excretion, with some variations depending on dietary intake and individual metabolism.

Pregnancy

Silicon is generally considered safe during pregnancy, as it is a naturally occurring element in the human body. However, specific recommendations regarding supplementation should be followed based on the advice of a healthcare provider.

Breast-feeding

Silicon is present in breast milk in small amounts. Its safety during breastfeeding is generally regarded as acceptable, although supplementation should be approached with caution and under medical advice.

Storage

Silicon should be stored in a cool, dry place, protected from light and moisture. Follow specific storage recommendations provided by the manufacturer if available.