What it does
Ginali is a medication that is used to treat certain health conditions.
Commonly used for: irregular periods, polycystic ovary syndrome (PCOS)
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Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:42 · updated 2026-09-29 04:33:05
About this medicine
Ginali is a medication that is used to treat certain health conditions.
What it treats
- irregular periods
- polycystic ovary syndrome (PCOS)
How it works
Ginali helps to regulate hormones in the body, which can improve menstrual cycles and other related symptoms.
Who it's for
This medication is for individuals experiencing hormonal imbalances, particularly women with irregular periods or PCOS.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: ginali
Ginali is a combination oral contraceptive that contains ethinyl estradiol and a progestin, typically drospirenone. It is used primarily for the prevention of pregnancy. The formulation may also have additional benefits such as regulating menstrual cycles and reducing menstrual-related symptoms.
Indications
- Contraception
- Regulation of menstrual cycles
- Management of dysmenorrhea
- Treatment of acne in females
- Reduction of premenstrual syndrome (PMS) symptoms
Dosage
Children: For paediatric patients, specifically females of reproductive age, the dosage should be determined based on individual assessment and should adhere to guidelines for combined oral contraceptives, typically beginning at age 16 or older. Refer to the BNF for Children for specific recommendations.
Adults: The recommended dosage for adults is usually one tablet taken orally once daily, at the same time each day, for 21 days, followed by a 7-day pill-free interval.
Mechanism of action
Ginali works by inhibiting ovulation through the suppression of gonadotropin release from the pituitary gland. Ethinyl estradiol and drospirenone alter the endometrial lining, making it less favorable for implantation, and increase the viscosity of cervical mucus, thereby hindering sperm passage.
Pharmacodynamics
The pharmacodynamic effects of Ginali include its ability to modulate the menstrual cycle, alleviate dysmenorrhea, and reduce the risk of ovarian cysts. It also provides contraceptive efficacy through multiple mechanisms, including preventing ovulation and altering the endometrial environment.
Pharmacokinetics
Ethinyl estradiol and drospirenone are well absorbed after oral administration. Ethinyl estradiol has a half-life of approximately 24 hours, while drospirenone has a half-life that ranges from 25 to 30 hours. Both drugs are metabolized in the liver, with drospirenone being eliminated primarily through renal excretion.
Contra-indications
- Hypersensitivity to ginali or any of its components
- Pregnancy or suspected pregnancy
- Severe liver disease
- Severe renal impairment
- History of thromboembolic disorders
Adverse effects
- Nausea
- Headache
- Breast tenderness
- Mood changes
- Weight gain
- Menstrual irregularities
- Thromboembolic events
Interactions
- Antibiotics may reduce the effectiveness of ginali
- Antiepileptics may lower plasma concentrations of ginali
- St. John's Wort may decrease the efficacy of ginali
- Other drugs metabolized by CYP450 enzymes may interact with ginali
Precautions
- Monitor for signs of thromboembolic events
- Use with caution in patients with a history of depression
- Consider alternate contraceptive methods in cases of drug interactions
- Regular health check-ups are recommended while using ginali
Pregnancy
Ginali is contraindicated in pregnancy due to potential risks to the fetus.
Breast-feeding
Ginali may be excreted in breast milk; caution is advised when administering to breastfeeding mothers.
Storage
Store in a cool, dry place, away from light. Keep out of reach of children.
Formulations
- Oral tablets
- Transdermal patches
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.