GYNO-TRAVOGEN 600 MG OVULES
ISOCONAZOLE NITRATE
What it does
Isoconazole is an antifungal medication used to treat skin infections caused by fungi.
Commonly used for: fungal skin infections, ringworm (tinea), athlete's foot (tinea pedis), jock itch (tinea cruris)
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Sourcing - Kenya onlyRegistration & product details
Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:38 · updated 2026-09-19 04:30:21
About this medicine
Isoconazole is an antifungal medication used to treat skin infections caused by fungi.
What it treats
- fungal skin infections
- ringworm (tinea)
- athlete's foot (tinea pedis)
- jock itch (tinea cruris)
How it works
Isoconazole works by stopping the growth of fungus on the skin, helping to clear up the infection.
Who it's for
Isoconazole is suitable for adults and children who have fungal skin infections.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: isoconazole
BNF-referencedIsoconazole is an antifungal agent belonging to the imidazole class of antifungals. It is primarily used topically to treat superficial fungal infections, including tinea and candidiasis. It exhibits activity against a broad spectrum of fungi, making it useful in various dermatological conditions. Isoconazole works by disrupting the synthesis of ergosterol, an essential component of fungal cell membranes.
Indications
- Superficial fungal infections
- Tinea (e.g., tinea pedis, tinea cruris, tinea corporis)
- Candidiasis (cutaneous candidiasis)
Dosage
Children: Refer to the BNF for Children for appropriate dosing information, as pediatric dosages may vary based on age, weight, and specific conditions.
Adults: Apply a thin layer of isoconazole cream or ointment to the affected area once or twice daily, as directed by a healthcare provider.
Mechanism of action
Isoconazole exerts its antifungal effects through the inhibition of ergosterol biosynthesis by interfering with the enzyme lanosterol 14-alpha-demethylase. This leads to a disruption of the fungal cell membrane, resulting in increased membrane permeability and ultimately cell death. The pathway involves the molting hormone biosynthesis pathway in fungi.
Pharmacodynamics
Isoconazole demonstrates fungicidal properties against a variety of fungi. Its efficacy is enhanced by its ability to penetrate the stratum corneum, allowing for localized treatment of fungal infections. The drug's effectiveness is also attributed to its ability to alter the fungal cell membrane structure, leading to increased permeability and leakage of cellular contents.
Pharmacokinetics
Isoconazole is primarily applied topically, which limits systemic absorption and minimizes potential systemic side effects. The pharmacokinetics of isoconazole indicate minimal absorption through intact skin, but it can be absorbed in significant amounts from damaged skin. Its metabolism and elimination details are not extensively documented, but topical application results in localized concentrations sufficient for antifungal activity.
Pregnancy
Isoconazole should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is important to consult healthcare professionals before use.
Breast-feeding
Isoconazole is not recommended during breastfeeding due to lack of sufficient data on its safety. Consultation with healthcare professionals is advised.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: isoconazole
PubChem CID 3760Molecular formula: C18H14Cl4N2O
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.