What it does
Polygeline is a substance used to help increase blood volume and improve circulation during medical procedures.
Commonly used for: low blood pressure (hypotension), shock, during surgery
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Source: Tanzania Medicines and Medical Devices Authority · fetched 2026-03-11 23:44:18 · updated 2026-09-28 03:00:45
About this medicine
Polygeline is a substance used to help increase blood volume and improve circulation during medical procedures.
What it treats
- low blood pressure (hypotension)
- shock
- during surgery
How it works
Polygeline works by drawing fluid into the blood vessels, helping to restore blood volume and support the body's circulation.
Who it's for
Polygeline is for patients who need help with blood volume, particularly during surgeries or in emergency situations.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: polygeline
Polygeline is a synthetic colloid that is used primarily as a plasma substitute in the management of hypovolemia and to maintain blood volume during surgical procedures. It is derived from gelatin and is known for its ability to expand plasma volume effectively while having a low incidence of adverse reactions compared to other colloids. Polygeline is often preferred in situations where rapid volume restoration is required.
Indications
- Hypovolemia
- Fluid resuscitation during surgical procedures
- Shock
- Burns
Dosage
Children: Refer to BNF for Children for appropriate dosing information.
Adults: Refer to specific clinical guidelines and BNF for dosing recommendations.
Mechanism of action
Polygeline works by increasing oncotic pressure within the vascular compartment, which draws fluid into the intravascular space from the interstitial compartments. This helps to expand blood volume and improve circulation, particularly in cases of hypovolemia due to trauma, surgery, or other causes.
Pharmacodynamics
Polygeline exhibits a rapid onset of action, with effects on plasma volume restoration observable within minutes of administration. Its colloidal properties allow it to maintain plasma volume for a sustained period, although the duration of action may vary depending on the patient's condition and the volume of fluid administered. The safety profile of polygeline is generally favorable, with minimal risk of allergic reactions or anaphylaxis compared to other colloids.
Pharmacokinetics
Polygeline is administered intravenously, where it is rapidly distributed into the vascular space. The elimination half-life is variable, influenced by factors such as the patient's renal function and fluid balance. Polygeline is metabolized in the liver and excreted primarily through the kidneys. Its colloidal nature means that it does not distribute into the interstitial space as readily as crystalloids, allowing it to maintain intravascular volume longer.
Contra-indications
- Hypersensitivity to polygeline or any of its components
- Severe dehydration
- Active bleeding disorders
Adverse effects
- Allergic reactions including rash and itching
- Headache
- Nausea and vomiting
- Hypotension
- Tachycardia
- Fluid overload
Interactions
- Caution when used with anticoagulants, as it may enhance the risk of bleeding
- May interact with diuretics, leading to altered fluid balance
Precautions
- Use with caution in patients with renal impairment
- Monitor fluid balance in patients with heart failure or hypertension
- Assess for potential allergic reactions prior to administration
Pregnancy
There are limited data on the use of polygeline during pregnancy. Use only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether polygeline is excreted in human milk. Caution should be exercised when administering to nursing mothers.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
Formulations
- Intravenous solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.