Hexaspray

Indications

• Oral infections
• Pharyngitis
• Tonsillitis
• Dental infections
• Upper respiratory tract infections

Dosage

Children: Refer to the BNF for Children for specific dosing recommendations based on age and weight.

Adults: Refer to the BNF for specific dosing recommendations based on the formulation used and the indication.

Mechanism of action

Biclotymol works by disrupting the bacterial cell membrane integrity, leading to cell lysis and death. It demonstrates bactericidal activity against a range of gram-positive and gram-negative bacteria. The presence of chlorine atoms in its structure contributes to its antimicrobial effectiveness, allowing it to interfere with bacterial metabolism and replication.

Pharmacodynamics

Biclotymol exhibits dose-dependent antibacterial activity, which is crucial for its effectiveness in treating infections. Its bactericidal properties are enhanced in the presence of certain inflammatory conditions, which may increase local concentrations of the drug. The drug also has anti-inflammatory effects, aiding in the reduction of symptoms like swelling and pain associated with infections.

Pharmacokinetics

The pharmacokinetics of biclotymol are characterized by its local application, leading to minimal systemic absorption. This property enhances its safety profile, as significant systemic effects are unlikely. The drug is primarily excreted unchanged, with a rapid onset of action observed upon local administration. Its half-life and detailed metabolic pathways have not been extensively studied, but the rapid action suggests effective local tissue penetration.

Pregnancy

There is limited data on the use of biclotymol during pregnancy. Caution is advised, and it should only be used if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Biclotymol is excreted in breast milk. Caution is recommended when administering to breastfeeding mothers.

Storage

Store at room temperature, away from light and moisture. Keep out of reach of children.

Formulations

• {'formulation': 'Oral solution', 'strength': '10 mg/5 mL'}
• {'formulation': 'Tablet', 'strength': '100 mg'}