HYTAN-40
Termisartan USP 40mg
What it does
Termisartan is a medication used to help lower blood pressure and protect kidney function.
Commonly used for: high blood pressure (hypertension), kidney disease related to diabetes
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Rwanda Food and Drugs Authority · fetched 2026-03-11 22:07:20 · updated 2026-09-21 02:30:20
About this medicine
Termisartan is a medication used to help lower blood pressure and protect kidney function.
What it treats
- high blood pressure (hypertension)
- kidney disease related to diabetes
How it works
Termisartan works by relaxing blood vessels, which helps to lower blood pressure and improve blood flow.
Who it's for
This medication is for adults who need help controlling their blood pressure or protecting their kidneys.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: termisartan
Telmisartan is an angiotensin II receptor antagonist (ARB) used primarily for the treatment of hypertension and for cardiovascular risk reduction in certain populations. It works by blocking the action of angiotensin II, a potent vasoconstrictor, leading to vasodilation and a subsequent decrease in blood pressure.
Indications
- Hypertension
- Cardiovascular risk reduction in patients unable to take ACE inhibitors
- Heart failure
Dosage
Children: Refer to the BNF for Children for appropriate dosing in pediatric patients.
Adults: Refer to the BNF for specific dosing guidelines based on the condition being treated.
Mechanism of action
Telmisartan selectively blocks the angiotensin II type 1 (AT1) receptor, inhibiting the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in lowered blood pressure and reduced workload on the heart.
Pharmacodynamics
Telmisartan decreases plasma aldosterone levels, which leads to increased sodium and water excretion. Its antihypertensive effects are typically observed within 3 hours after oral administration, with peak effects occurring around 4 to 6 hours post-dose. The antihypertensive action is maintained over 24 hours.
Pharmacokinetics
Telmisartan is well absorbed after oral administration, with a bioavailability of about 50%. It is highly protein-bound (approximately 99.5%) and has a volume of distribution of about 15 liters. The drug undergoes minimal hepatic metabolism, primarily through glucuronidation, and is excreted mainly in the feces. The elimination half-life is approximately 24 hours, allowing for once-daily dosing.
Contra-indications
- Hypersensitivity to telmisartan or any of the excipients
- Pregnancy
- Severe hepatic impairment
- Biliary obstructive disorders
- Severe renal impairment or renal artery stenosis
Adverse effects
- Dizziness
- Fatigue
- Hypotension
- Hyperkalemia
- Renal impairment
- Angioedema
- Gastrointestinal disturbances
Interactions
- Other antihypertensive agents may enhance the hypotensive effect
- Potassium-sparing diuretics or potassium supplements may increase the risk of hyperkalemia
- NSAIDs may reduce the antihypertensive effect
- Lithium levels may increase when combined with telmisartan
Precautions
- Monitor renal function before and during treatment
- Caution in patients with a history of angioedema
- Use with caution in patients with heart failure or aortic stenosis
- Regular monitoring of potassium levels is advised
Pregnancy
Telmisartan is contraindicated in pregnancy due to potential harm to the fetus.
Breast-feeding
It is not known if telmisartan is excreted in human milk, use with caution.
Storage
Store at room temperature, away from moisture and heat.
Formulations
- Tablets: 20 mg, 40 mg, 80 mg
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.