Registered Malawi · PMRA

LISTERFLUOR-FLUORIDE DENTAL RINSE 2.21MG/10ML SOLUTION

SODIUM FLUORIDE

PMPB/PL48/23 SOLUTION

What it does

Fluoride is a mineral that helps to strengthen teeth and prevent cavities.

Commonly used for: tooth decay prevention, strengthening teeth

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Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.

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Registration & product details

Registration no.
PMPB/PL48/23
Registration date
05/02/2001
Expiry date
30/06/2001
Status
Registered
Active ingredient
SODIUM FLUORIDE
Dosage form
SOLUTION
Strength
-
Pack size
-
Therapeutic class
-
Manufacturer / MAH
-
Applicant / LTR
-
Country of origin
-

Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:44 · updated 2026-09-22 04:33:04

Disclaimer: This information is sourced from Pharmacy and Medicines Regulatory Authority (Malawi). Always consult a qualified healthcare professional before using any medication.

About this medicine

Fluoride is a mineral that helps to strengthen teeth and prevent cavities.

What it treats

  • tooth decay prevention
  • strengthening teeth

How it works

Fluoride works by making the tooth enamel stronger, which helps to resist decay and cavities.

Who it's for

Fluoride is suitable for people of all ages, especially children and teenagers who are still developing their teeth.

AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.

Clinical monograph: fluoride

BNF-referenced

Fluoride is a negatively charged ion derived from fluorine, known for its role in dental health, particularly in the prevention of dental caries. It is used in various formulations, including topical gels and rinses, as well as in systemic applications such as water fluoridation. Fluoride enhances the remineralization of tooth enamel and inhibits the demineralization process caused by acid-producing bacteria in the mouth.

Indications

  • Prevention of dental caries
  • Treatment of dental hypersensitivity
  • Topical application for high caries risk patients

Dosage

Children: Refer to the BNF for Children for specific paediatric dosage recommendations, which are typically based on age and dental health needs.

Adults: Refer to the BNF for specific adult dosage recommendations, which may vary based on the formulation and indication.

Mechanism of action

Fluoride acts primarily by enhancing the mineralization process of the tooth enamel through the formation of fluorapatite, which is more resistant to acid dissolution than hydroxyapatite. It also inhibits the activity of specific enzymes in bacteria that contribute to acid production, thereby reducing the overall cariogenic potential of dental plaque.

Pharmacodynamics

Fluoride exhibits a dose-dependent effect on dental health, with low concentrations promoting enamel remineralization and higher concentrations potentially toxic to bacteria. Its effectiveness is attributed to its ability to integrate into the crystalline structure of teeth, leading to improved resistance to acid attacks. Additionally, fluoride can modulate the metabolism of oral bacteria, reducing their ability to produce acid from fermentable carbohydrates.

Pharmacokinetics

Fluoride is readily absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1 to 2 hours after ingestion. It is distributed throughout the body, with significant accumulation in bones and teeth. The elimination half-life varies, but fluoride is primarily excreted unchanged via the kidneys. The clearance rate can be influenced by renal function as well as dietary factors.

Pregnancy

Fluoride is generally considered safe during pregnancy when used in appropriate doses for dental health. However, excessive intake should be avoided.

Breast-feeding

Fluoride is excreted in breast milk in small amounts. It is generally regarded as safe for breastfeeding mothers when used appropriately.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

PubChem / pathway

AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.

Molecular reference: fluoride

PubChem CID 28179

Molecular formula: F-

Biological pathways

fluoroacetate and fluorothreonine biosynthesis BioCyc superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle BioCyc superpathway of glycolysis and the Entner-Doudoroff pathway BioCyc Rubisco shunt BioCyc superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass BioCyc (aminomethyl)phosphonate degradation BioCyc photosynthetic 3-hydroxybutanoate biosynthesis (engineered) BioCyc L-tryptophan degradation I (via anthranilate) BioCyc D-sorbitol biosynthesis I BioCyc phenylacetate degradation I (aerobic) BioCyc D-galactarate degradation I BioCyc superpathway of L-lysine degradation BioCyc

Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.

This drug in other countries

The same active ingredient registered across other registries we cover - including different brands.

Tanzania 8 products
View all 8 in Tanzania →
Kenya 3 products
Rwanda 1 product