LULYERA CREAM
LULICONAZOLE
What it does
Luliconazole is a medication used to treat fungal skin infections.
Commonly used for: athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris)
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:04:54 · updated 2026-09-18 02:33:08
About this medicine
Luliconazole is a medication used to treat fungal skin infections.
What it treats
- athlete's foot (tinea pedis)
- ringworm (tinea corporis)
- jock itch (tinea cruris)
How it works
It works by stopping the growth of the fungus that causes the infection.
Who it's for
It is for adults and children over the age of 12 who have a fungal skin infection.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: luliconazole
BNF-referencedLuliconazole is an antifungal agent primarily used for the treatment of dermatophyte infections. It is effective against various fungal pathogens, particularly those affecting the skin. Luliconazole is formulated as a topical solution and is known for its relatively low side effect profile and ease of application. Its use has been increasingly recognized in the management of superficial fungal infections.
Indications
- Tinea corporis
- Tinea cruris
- Tinea pedis
- Dermatophyte infections
Dosage
Children: Refer to the BNF for Children for specific dosing recommendations for pediatric patients.
Adults: Apply a thin layer of luliconazole to the affected area once daily for a duration of 1 to 2 weeks, depending on the specific infection being treated.
Mechanism of action
The exact mechanism of action for luliconazole's antifungal activity is not fully understood, but it is believed to inhibit the enzyme lanosterol demethylase. This enzyme is essential for the synthesis of ergosterol, which is a critical component of fungal cell membranes. By inhibiting this enzyme, luliconazole disrupts the integrity of the fungal cell membrane, leading to cell death.
Pharmacodynamics
Luliconazole demonstrates fungicidal activity against organisms like Trichophyton rubrum and Epidermophyton floccosum. Its action is thought to be primarily through the alteration of fungal cell membranes, which compromises the structure and function of the fungi, ultimately leading to their death.
Pharmacokinetics
Luliconazole is administered topically, which limits its systemic absorption. The pharmacokinetics of luliconazole involve localized action at the site of application, minimizing the risk of systemic side effects. Due to its topical formulation, specific pharmacokinetic parameters such as absorption, distribution, metabolism, and excretion in humans are not extensively detailed in the literature.
Adverse effects
- Application site reactions
- Burning sensation
- Itching
- Erythema
Precautions
- Avoid contact with eyes
- Do not apply to broken skin
Pregnancy
Luliconazole should only be used in pregnancy if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Caution should be exercised when luliconazole is administered to nursing mothers.
Storage
Store at room temperature, away from moisture and heat.
Formulations
- Topical cream
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: luliconazole
PubChem CID 3003141Molecular formula: C14H9Cl2N3S2
Mechanism of action
The exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes.
Pharmacodynamics
Luliconazole kills the organisms Trichophyton rubrum and Epidermophyton floccosum, most likely by altering their fungal cell membranes.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.