NORASH CREAM

Indications

• Skin irritations
• Diaper rash
• Contact dermatitis
• Eczema
• Psoriasis
• Minor burns

Dosage

Children: For infants and children, apply a thin layer to the affected area as needed, ensuring the skin is clean and dry before application. Refer to specific pediatric guidelines for more detailed dosing information.

Adults: Apply a thin layer to the affected area as needed, ensuring the skin is clean and dry before application.

Mechanism of action

Dimethicone works by forming a protective layer on the skin, which helps to prevent transepidermal water loss and provides a smooth, silky feel. Zinc, on the other hand, has been shown to have anti-inflammatory properties, aiding in the reduction of redness and irritation. It can also promote wound healing and offers antimicrobial benefits, which can help prevent infection in compromised skin.

Pharmacodynamics

The pharmacodynamics of dimethicone-zinc primarily involves its emollient and barrier-forming properties, which enhance skin hydration and protection. Zinc's role in the formulation contributes to its ability to soothe inflammation and promote skin repair. The combination thus offers a multifaceted approach to skin care, addressing both protective and healing needs.

Pharmacokinetics

Dimethicone is not absorbed through the skin and acts locally at the site of application. Its effects are primarily topical, providing a physical barrier rather than systemic pharmacological effects. Zinc can be absorbed in small amounts through the skin, but the extent of systemic absorption from topical application is minimal. The onset of action is typically rapid, with effects observed shortly after application.

Pregnancy

Dimethicone-zinc is generally considered safe for use during pregnancy, but it is advisable to consult a healthcare professional before use.

Breast-feeding

Dimethicone-zinc is considered safe for breastfeeding mothers, but consulting a healthcare professional is recommended.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Formulations

• Topical cream
• Ointment
• Gel

Indications

• Minor cuts
• Abrasions
• Skin irritations
• Insect bites
• Minor burns

Dosage

Children: For paediatric patients, the same application frequency as adults is generally recommended, but it is advisable to consult the BNF for Children for specific guidance.

Adults: Apply the preparation to the affected area 1 to 3 times daily, or as directed by a healthcare professional.

Mechanism of action

Cetrimide works by disrupting the cell membranes of bacteria, leading to their death. It exhibits broad-spectrum antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria. Oxidecalamine, on the other hand, provides a protective barrier over the skin, reduces irritation, and aids in the healing process by soothing inflamed skin.

Pharmacodynamics

The pharmacodynamic properties of oxidecalaminecetrimide are characterized by its antiseptic and soothing effects. Cetrimide's ability to kill bacteria and prevent infection is complemented by oxidecalamine's protective and anti-inflammatory actions, making it effective in treating minor cuts, abrasions, and skin irritations.

Pharmacokinetics

As a topical preparation, the pharmacokinetics of oxidecalaminecetrimide are primarily localized to the site of application. Systemic absorption is minimal, which reduces the risk of systemic side effects. The duration of action depends on the specific formulation and the condition being treated, but it is generally effective for the duration of its application.

Adverse effects

• Local skin irritation
• Allergic reactions
• Erythema
• Dryness of the skin

Precautions

• Avoid contact with eyes
• Use with caution in patients with sensitive skin or allergies

Pregnancy

Safety during pregnancy has not been established. Use only if clearly needed and prescribed by a healthcare provider.

Breast-feeding

It is unknown if oxidecalaminecetrimide is excreted in human milk. Caution is advised when used by nursing mothers.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Formulations

• Topical cream
• Topical lotion