PARVON INJECTION

Indications

• Theileriosis in cattle
• Protozoan infections in veterinary medicine

Dosage

Children: Refer to the BNF for Children for appropriate dosing guidelines in paediatric patients.

Adults: Refer to the BNF for specific dosing information as it may vary based on the condition being treated.

Mechanism of action

Parvaquone exerts its antiparasitic effects by inhibiting mitochondrial electron transport in protozoan parasites. It disrupts the redox reaction processes essential for the generation of ATP, leading to energy depletion in the parasites, which ultimately results in cell death. This mechanism is particularly effective against Theileria species, which are responsible for the disease Theileriosis.

Pharmacodynamics

Parvaquone demonstrates a selective toxicity towards protozoan parasites, particularly Theileria species, by targeting their unique mitochondrial processes. Its effectiveness is attributed to the compound's ability to interfere with energy metabolism, leading to impaired growth and replication of the parasites. Parvaquone has a rapid onset of action, and its efficacy can vary based on the specific strain of the parasite and the dosage administered.

Pharmacokinetics

Parvaquone is absorbed following administration and is distributed throughout the body, particularly in tissues where Theileria species reside. The drug undergoes metabolic processes predominantly in the liver, and its elimination half-life can vary based on species and individual metabolic rates. The excretion of parvaquone occurs mainly through the feces, with a minor fraction eliminated via urine. The pharmacokinetics may be influenced by factors such as age, health status, and concurrent medications.

Pregnancy

There is insufficient data on the use of parvaquone in pregnant women. Use with caution and only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

It is unknown whether parvaquone is excreted in human milk. Caution is advised when administering to nursing mothers.

Storage

Store in a cool, dry place away from light. Keep out of reach of children.

Formulations

• {'formulation': 'Tablet', 'strength': '100 mg'}
• {'formulation': 'Suspension', 'strength': '50 mg/5 mL'}