Flumesol-200 WS

Indications

• Urinary tract infections
• Gastrointestinal infections
• Respiratory infections
• Skin and soft tissue infections

Dosage

Children: Refer to the BNF for Children for appropriate dosing in paediatric patients, as it varies with age and weight.

Adults: Refer to the BNF for specific dosing guidelines based on the type and severity of infection.

Mechanism of action

Flumequine exerts its antibacterial effects by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication, transcription, and repair. This inhibition leads to disruption of DNA supercoiling and ultimately results in bacterial cell death. The drug's action is concentration-dependent, meaning that higher drug concentrations lead to greater efficacy.

Pharmacodynamics

Flumequine demonstrates time-dependent killing, where the duration of exposure above the minimum inhibitory concentration (MIC) is important for its effectiveness. It has a broad spectrum of activity, particularly against enteric bacteria. Resistance may develop through mutations in DNA gyrase or topoisomerase IV or through efflux mechanisms in bacteria. The drug is typically bactericidal rather than bacteriostatic.

Pharmacokinetics

Flumequine is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1 to 2 hours. It has a bioavailability of approximately 60-70%. The drug is widely distributed in body tissues and fluids, including lung, liver, and kidney. It is metabolized primarily in the liver, with a half-life of about 5 to 10 hours, and is excreted mainly via the kidneys. Renal impairment may affect the clearance of flumequine.

Pregnancy

Flumequine should not be used during pregnancy unless the potential benefits outweigh the risks, as safety in human pregnancy has not been established.

Breast-feeding

Flumequine is not recommended during breastfeeding as it is not known whether it is excreted in human milk.

Storage

Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.

Formulations

• Tablets
• Injectable solution