Registered Botswana · BoMRA

MICHOL

methylcellulose

BOT1101851 TABLET alimentary tract and metabolism INN generic

What it does

Methylcellulose is a type of fiber that helps relieve constipation and can also be used as a thickening agent in foods.

Commonly used for: constipation, irregular bowel movements

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Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.

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Registration & product details

Registration no.
BOT1101851
Registration date
2011-10-06
Expiry date
-
Status
Registered/Compliant
Active ingredient
methylcellulose
Dosage form
TABLET
Strength
-
Pack size
-
Therapeutic class
-
ATC class (WHO)
A06AC - Bulk-forming laxatives
Drug group
ALIMENTARY TRACT AND METABOLISM
RxNorm RxCUI
6873
Manufacturer / MAH
Aurobindo Pharma
Applicant / LTR
INGELHEIM PHARMACEUTICALS (PTY) LTD Private Bag X3032, Randburg, 2125, South Africa
Country of origin
India
Manufacturer location
Galaxy, Floors: 22-24 Plot No.1, Survey No.83/1 Hyderabad Knowledge City Raidurg Panmaktha, Silpa Gram Craft Village, Hyderabad, Rai Durg, Telangana 500032, India

Source: Botswana Medicines Regulatory Authority · fetched 2026-04-15 20:41:54 · updated 2026-05-12 08:02:32

Disclaimer: This information is sourced from Botswana Medicines Regulatory Authority (Botswana). Always consult a qualified healthcare professional before using any medication.

About this medicine

Methylcellulose is a type of fiber that helps relieve constipation and can also be used as a thickening agent in foods.

What it treats

  • constipation
  • irregular bowel movements

How it works

Methylcellulose absorbs water in the intestines, which helps to form a soft stool and makes it easier to pass.

Who it's for

It is suitable for adults and children who need help with bowel regularity.

AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.

Clinical monograph: Methylcellulose

BNF-referenced

Methylcellulose is a bulk-forming laxative that is primarily used to relieve constipation by increasing the bulk of the stool, which stimulates peristalsis and promotes bowel movements. It is a non-digestible polysaccharide derived from cellulose, and it acts by absorbing water in the intestines, forming a gel-like substance that adds bulk to the stool.

Indications

  • Constipation
  • Faecal impaction

Dosage

Children: For children aged 1 month to 5 years, the recommended dosage is 2.5 to 5 mL twice daily. Dosage may vary based on individual response and should be guided by a healthcare professional.

Adults: For adults, the typical dosage is 1 to 2 tablespoons (around 15 to 30 mL) mixed with at least 240 mL of water, taken up to three times daily. It is important to ensure adequate fluid intake to avoid gastrointestinal obstruction.

Mechanism of action

Methylcellulose acts as a bulk-forming laxative by absorbing water in the gastrointestinal tract. This increases the stool's bulk and promotes bowel motility through mechanical stimulation of the intestinal walls, which enhances peristalsis. It does not undergo significant metabolism and directly influences the physical properties of the stool.

Pharmacodynamics

The pharmacodynamic profile of methylcellulose indicates that it increases stool bulk and moisture content, facilitating easier passage of stool. The osmotic effect helps to soften the stool, while the bulk created stimulates intestinal contractions, reducing the time stool remains in the colon and alleviating constipation.

Pharmacokinetics

Methylcellulose is not absorbed systemically as it is a non-digestible fiber. Its effects are localized to the gastrointestinal tract. After oral administration, it acts primarily in the intestines, where it retains water to form a gel-like mass. The onset of action may vary, with effects usually observed within 24 to 72 hours.

Adverse effects

  • abdominal discomfort
  • bloating
  • diarrhea
  • nausea

Precautions

  • Ensure adequate fluid intake to prevent intestinal blockage.
  • Use cautiously in patients with pre-existing gastrointestinal disorders.

Pregnancy

Methylcellulose is generally considered safe during pregnancy. However, it is advisable to consult with a healthcare professional before use.

Breast-feeding

Methylcellulose is excreted in breast milk. Consult a healthcare provider for advice on use while breastfeeding.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Formulations

  • Oral liquid
  • Granules
BNF for Children 2019-2020 p.64 PubChem / pathway

AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.

This drug in other countries

The same active ingredient registered across other registries we cover - including different brands.

Tanzania 20 products
View all 20 in Tanzania →
Kenya 3 products
Ghana 2 products
Malawi 1 product
Zambia 1 product