Registered Kenya · PPB

NEPICIL-10NL

CILNIDIPINE

H2020/CTD6103/1672ER 10MG GENERIC/BIOSIMILARS

What it does

Cilnidipine is a medication used to help lower high blood pressure.

Commonly used for: high blood pressure (hypertension)

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Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.

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Registration & product details

Registration no.
H2020/CTD6103/1672ER
Registration date
2020-04-17 00:00:00
Expiry date
-
Status
Registered
Active ingredient
CILNIDIPINE
Dosage form
10MG
Strength
-
Pack size
10 TABLETS PACKED IN ONE BLISTER. SUCH 10 BLISTERS ARE PACKED IN A PRINTED CARTON WITH A PACKING INSERT.
Therapeutic class
GENERIC/BIOSIMILARS
Manufacturer / MAH
Medfo Kenya
Applicant / LTR
MEDFO KENYA LIMITED
Country of origin
FOREIGN
Manufacturer location
SAMEER AFRICA, SAMEER BUSINESS COMPLEX, Enterprise Rd, Nairobi, Kenya

Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:45:55 · updated 2026-08-03 02:54:58

Disclaimer: This information is sourced from Pharmacy and Poisons Board (Kenya). Always consult a qualified healthcare professional before using any medication.

About this medicine

Cilnidipine is a medication used to help lower high blood pressure.

What it treats

  • high blood pressure (hypertension)

How it works

Cilnidipine works by relaxing the blood vessels, which helps to reduce the pressure of blood flowing through them.

Who it's for

This medication is for adults who need help controlling their high blood pressure.

AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.

Clinical monograph: cilnidipine

BNF-referenced

Cilnidipine is a calcium channel blocker primarily used for the treatment of hypertension. It exhibits a dual mechanism of action by blocking both L-type and N-type calcium channels, leading to vasodilation and reduced sympathetic nervous system output. This results in effective blood pressure control with a lower risk of reflex tachycardia compared to some other antihypertensives.

Indications

  • Hypertension
  • Essential hypertension

Dosage

Children: Refer to BNF for Children for specific dosing guidance.

Adults: Refer to BNF for specific dosing guidance.

Mechanism of action

Cilnidipine acts on the L-type calcium channels of blood vessels by blocking the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. It also works on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of norepinephrine and suppressing the increase in stress blood pressure.

Pharmacodynamics

Administration of cilnidipine has been shown to present an antisympathetic profile in vitro and in vivo. It decreases blood pressure safely and effectively without excessive blood pressure reduction or tachycardia.

Contra-indications

  • Hypersensitivity to cilnidipine or any of its components
  • Severe hypotension
  • Aortic stenosis
  • Cardiogenic shock

Adverse effects

  • Headache
  • Dizziness
  • Flushing
  • Peripheral edema
  • Palpitations
  • Constipation
  • Nausea

Interactions

  • May enhance the effect of other antihypertensive agents
  • Caution when used with calcium channel blockers
  • May interact with drugs that affect cytochrome P450 enzymes

Precautions

  • Use with caution in patients with hepatic or renal impairment
  • Monitor blood pressure regularly during therapy
  • Caution in elderly patients and those with a history of heart failure

Pregnancy

Cilnidipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult relevant guidelines.

Breast-feeding

It is not known whether cilnidipine is excreted in human milk. Caution should be exercised when administering to a nursing mother.

Storage

Store at room temperature, away from moisture and heat. Keep out of reach of children.

Formulations

  • Tablets: 10 mg, 20 mg
PubChem / pathway

AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.

Molecular reference: cilnidipine

PubChem CID 5282138

Molecular formula: C27H28N2O7

Mechanism of action

Cilnidipine acts on the L-type calcium channels of blood vessels by blocking the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. Cilnidipine also works on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of norepinephrine and suppressing the increase in stress blood pressure.

Pharmacodynamics

Administration of cilnidipine has been shown to present an antisympathetic profile in vitro and in vivo. It decreases blood pressure safely and effectively without excessive blood pressure reduction or tachycardia.

Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.

This drug in other countries

The same active ingredient registered across other registries we cover - including different brands.

Tanzania 9 products
View all 9 in Tanzania →
Zambia 4 products
Botswana 3 products
Malawi 2 products
Rwanda 2 products