TRIBULUS TERRESTRIS 250MG CAPSULE

Indications

• Libido enhancement
• Support for athletic performance
• General vitality improvement

Dosage

Children: There is insufficient evidence or guidance for pediatric dosing; consultation with a healthcare professional is recommended.

Adults: Dosage recommendations vary widely, and individuals are advised to follow product-specific instructions or consult with a healthcare provider.

Mechanism of action

Tribulus terrestris is thought to exert its effects primarily by increasing the levels of luteinizing hormone (LH) and testosterone. The saponins present in the plant may stimulate the secretion of hormones from the pituitary gland, leading to enhanced testosterone production in the testes. This increase in testosterone may contribute to improved libido and physical performance.

Pharmacodynamics

The pharmacodynamic effects of Tribulus terrestris include modulation of hormone levels, particularly testosterone and luteinizing hormone. It may enhance libido, improve mood, and potentially support muscle mass and strength when used in conjunction with exercise. The exact dose-response relationship and the full scope of its effects on human physiology require further investigation.

Pharmacokinetics

The pharmacokinetics of Tribulus terrestris, including absorption, distribution, metabolism, and excretion, are not well characterized in clinical studies. However, it is generally believed that the saponins and other active compounds are readily absorbed in the gastrointestinal tract. The half-life and elimination pathways are not well defined, necessitating further research to clarify these aspects.

Pregnancy

The safety of terrestris during pregnancy has not been established. Use should be avoided unless clearly necessary.

Breast-feeding

It is not known whether terrestris is excreted in human milk. Caution is advised when administering to nursing mothers.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Indications

• Low libido
• Erectile dysfunction
• Athletic performance enhancement
• Menstrual disorders

Dosage

Children: Refer to the BNF for Children for specific dosing information.

Adults: Refer to the BNF for specific dosing information.

Mechanism of action

Tribulus is thought to act through several mechanisms, primarily by increasing the levels of testosterone and other androgens in the body. This may occur through the stimulation of luteinizing hormone (LH) production, which in turn promotes testosterone synthesis in the Leydig cells of the testes. Additionally, its saponins may exert a mild diuretic effect and enhance nitric oxide production, leading to improved blood flow and muscle performance.

Pharmacodynamics

The pharmacodynamics of Tribulus involves its interaction with androgen receptors and the hypothalamic-pituitary-gonadal axis. The increase in testosterone levels can lead to improved libido, increased muscle mass, and enhanced physical performance. The diuretic effect may contribute to weight loss and improved body composition, although these claims require further clinical validation.

Pharmacokinetics

The pharmacokinetics of Tribulus is not thoroughly documented in the literature. However, it is believed that the active compounds are absorbed in the gastrointestinal tract, with bioavailability potentially affected by factors such as formulation and dosage. The metabolism of steroidal saponins likely involves hepatic pathways, and elimination is presumed to occur via renal excretion, although specific studies are lacking.

Pregnancy

There is insufficient reliable information about the safety of tribulus during pregnancy. It is recommended to avoid use.

Breast-feeding

Limited information is available regarding the excretion of tribulus in breast milk. It is advisable to avoid use during breastfeeding.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.